The amygdala: is it an essential component of the neural network for social cognition?
The amygdala: is it an essential component of the neural network for social cognition?
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DOI：
10.1016/s0028-3932(02)00154-9
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发表时间：
2003-01-01
期刊：
影响因子：
2.6
通讯作者：
Prather, M
中科院分区：
文献类型：
--
作者：
Amaral, DG;Capitanio, JP;Prather, M
从患有局灶性脑损伤的人类受试者和患有实验性损伤的动物受试者的观察结果表明，各种脑区域都参与了社会行为的调节。先前在猕猴身上进行的研究发现，杏仁核的损伤不仅会降低情绪反应，还会破坏正常的社会交往。我们已经重新研究了杏仁核病变和社会行为之间的关系，在成熟和新生恒河猴的队列中，这些恒河猴准备了选择性和完全的双侧鹅膏蕈氨酸杏仁复合体病变。这些动物在情感和社会行为上表现出明显的变化。我们将这些变化解释为由于失去了评估环境刺激作为潜在威胁的能力。然而，双侧杏仁核损伤的成年动物表现出正常的，甚至增加，与同种的社会互动。此外，新生动物，准备与杏仁核病变在2周龄，也表现出物种典型的社会行为，如面部表情的产生，梳理和游戏行为。这些结果反驳了杏仁核对解释社会交流或表达社会行为至关重要的观点。因为它确实参与了社会互动的“安全性”评估，我们相信它确实在调节生物体参与的社会行为量方面发挥了作用。然而，我们目前对本文标题中提出的问题的答案是否定的！(C)2002年由Elsevier Science Ltd.出版
Observations from human subjects with focal brain lesions and animal subjects with experimental lesions have implicated a variety of brain regions in the mediation of social behavior. Previous studies carried out in the macaque monkey found that lesions of the amygdala not only decrease emotional reactivity but also disrupt normal social interactions. We have re-investigated the relationship between amygdala lesions and social behavior in cohorts of mature and neonatal rhesus monkeys who were prepared with selective and complete bilateral ibotenic acid lesions of the amygdaloid complex. These animals display clear alterations in emotional and social behavior. We interpret these changes as due to a loss of the ability to evaluate environmental stimuli as potential threats. However, adult animals with bilateral lesions of the amygdala demonstrate normal, and even increased, social interactions with conspecifics. Moreover, neonatal animals, prepared with amygdala lesions at 2 weeks of age, also demonstrate species typical social behaviors such as the generation of facial expressions, grooming and play behavior. These results argue against the idea that the amygdala is essential for the interpretation of social communication or for the expression of social behavior. Because it does appear to participate in the evaluation of the "safety" of social interactions, we believe that it does have a role in modulating the amount of social behavior in which an organism will participate. However, our current answer to the question posed in the title of this paper is no! (C) 2002 Published by Elsevier Science Ltd.