Immuno gold nanocages with tailored optical properties for targeted photothermal destruction of cancer cells
Immuno gold nanocages with tailored optical properties for targeted photothermal destruction of cancer cells
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DOI：
10.1021/nl070345g
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发表时间：
2007-05-01
期刊：
影响因子：
10.8
通讯作者：
Li, Xingde
中科院分区：
文献类型：
--
作者：
Chen, Jingyi;Wang, Danling;Li, Xingde
具有相对小尺寸的金纳米笼（例如，类似于45 nm的边长），并且这些纳米笼的结构被定制以实现用于光热癌症治疗的近红外（NIR）区域中的强吸收。数值计算表明，纳米笼具有3.48 × 10（-14）m（2）的大吸收截面，有利于近红外辐射转化为热量。金纳米笼与单克隆抗体（抗HER 2）结合，以靶向乳腺癌细胞（SK-BR-3）表面过表达的表皮生长因子受体（EGFR）。我们的初步光热结果表明，纳米笼强烈吸收近红外区的光，强度阈值为1.5 W/cm（2），以诱导对癌细胞的热破坏。在1.5- 4.7W/cm ~ 2强度范围内，细胞损伤的圆形面积随辐照功率密度的增加而线性增加。这些结果表明，这种新型的生物共轭金纳米结构，免疫金纳米笼，可以作为一种有效的光热治疗剂用于癌症治疗。
Gold nanocages with a relatively small size (e.g., similar to 45 nm in edge length) have been developed, and the structure of these nanocages was tailored to achieve strong absorption in the near-infrared (NIR) region for photothermal cancer treatment. Numerical calculations show that the nanocage has a large absorption cross section of 3.48 x 10(-14) m(2), facilitating conversion of NIR irradiation into heat. The gold nanocages were conjugated with monoclonal antibodies (anti-HER2) to target epidermal growth factor receptors (EGFR) that are overexpressed on the surface of breast cancer cells (SK-BR-3). Our preliminary photothermal results show that the nanocages strongly absorb light in the NIR region with an intensity threshold of 1.5 W/cm(2) to induce thermal destruction to the cancer cells. In the intensity range of 1.5-4.7 W/cm(2), the circular area of damaged cells increased linearly with the irradiation power density. These results suggest that this new class of bioconjugated gold nanostructures, immuno gold nanocages, can potentially serve as an effective photothermal therapeutic agent for cancer treatment.