Clinical Immunology and Immunopathology of the Canine and Feline Intestine
Clinical Immunology and Immunopathology of the Canine and Feline Intestine
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DOI：
10.1016/j.cvsm.2011.01.004
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发表时间：
2011-03-01
影响因子：
1.9
通讯作者：
Allenspach, Karin
中科院分区：
文献类型：
--
作者：
Allenspach, Karin
粘膜免疫系统处于防御入侵病原体的最前沿，但与此同时，它必须保持对肠腔内共生菌和食物抗原的耐受性。先天免疫反应和共生微生物之间的相互作用对于维持这种平衡至关重要。在确定某些品种（例如德国牧羊犬）炎症性肠病的遗传易感性方面已经取得了巨大进展。讨论了几种免疫学标记物在炎症性肠病的诊断和治疗中的临床用途。
The mucosal immune system is at the forefront of defense against invading pathogens, but at the same time, it must maintain tolerance toward commensals and food antigens in the intestinal lumen. The interplay between the innate immune response and commensal microorganisms is essential to maintaining this balance. Great progress has been made in identifying some of the genetic predispositions underlying inflammatory bowel disease in certain breeds, such as the German shepherd dog. Several immunologic markers are discussed with respect to their clinical usefulness in the diagnosis and management of inflammatory bowel disease.