Campylobacter Colonization and Proliferation in the Broiler Chicken upon Natural Field Challenge Is Not Affected by the Bird Growth Rate or Breed
Campylobacter Colonization and Proliferation in the Broiler Chicken upon Natural Field Challenge Is Not Affected by the Bird Growth Rate or Breed
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DOI：
10.1128/aem.02162-14
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发表时间：
2014-11-01
影响因子：
4.4
通讯作者：
Koerhuis, Alfons N. M.
中科院分区：
文献类型：
--
作者：
Gormley, Fraser J.;Bailey, Richard A.;Koerhuis, Alfons N. M.
几十年来的研究一直试图阐明这种复杂关系的流行病学，并减少家禽中的携带，从而确定家禽和人类之间弯曲杆菌之间的人畜共患病关系。虽然许多工作都集中在帮助它成功污染鸡群(和其他动物宿主)的机制上，但在野外条件下仍然很难始终如一地排除弯曲杆菌。在英国家禽业中，有各种不同生长速度的禽类基因型可供选择，以满足市场需求和消费者偏好。然而，关于弯曲杆菌在这一现代肉鸡范围内是否存在任何差异，人们知之甚少。这项研究的目的是确定在自然商业群弯曲菌挑战后，生长速度或品种与盲肠弯曲菌浓度之间是否存在关系。在一项研究中，四个不同生长速度的纯系基因型被一起生长，而在第二个研究中，八个不同的商品肉鸡基因型被单独饲养。在这两项研究中，在42日龄时对盲肠弯曲菌浓度进行了测量，结果显示，在混合和单一基因型围栏中，不同基因类型的禽类的盲肠负荷没有显著差异。从公共卫生的角度来看，这一点很重要，并表明除了基因以外的其他潜在原因可能控制和影响弯曲杆菌在鸡体内的定植。需要进一步研究，以更好地了解定居动态和随后的扩散，以及减少家禽负担的新方法。
The zoonotic association between Campylobacter bacteria in poultry and humans has been characterized by decades of research which has attempted to elucidate the epidemiology of this complex relationship and to reduce carriage within poultry. While much work has focused on the mechanisms facilitating its success in contaminating chicken flocks (and other animal hosts), it remains difficult to consistently exclude Campylobacter under field conditions. Within the United Kingdom poultry industry, various bird genotypes with widely varying growth rates are available to meet market needs and consumer preferences. However, little is known about whether any differences in Campylobacter carriage exist across this modern broiler range. The aim of this study was to establish if a relationship exists between growth rate or breed and cecal Campylobacter concentration after natural commercial flock Campylobacter challenge. In one investigation, four pure line genotypes of various growth rates were grown together, while in the second, eight different commercial broiler genotypes were grown individually. In both studies, the Campylobacter concentration was measured in the ceca at 42 days of age, revealing no significant difference in cecal load between birds of different genotypes both in mixed- and single-genotype pens. This is important from a public health perspective and suggests that other underlying reasons beyond genotype are likely to control and affect Campylobacter colonization within chickens. Further studies to gain a better understanding of colonization dynamics and subsequent proliferation are needed, as are novel approaches to reduce the burden in poultry.