Convenient Synthesis of 4-Hydroxy-1,2-dihydroquinoline-3-carboxylate Derivatives and 4-Oxo-1,2,3,4-tetrahydroquinoline-3-carboxylates
Convenient Synthesis of 4-Hydroxy-1,2-dihydroquinoline-3-carboxylate Derivatives and 4-Oxo-1,2,3,4-tetrahydroquinoline-3-carboxylates
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4-羟基-1,2-二氢喹啉-3-羧酸酯衍生物和4-Oxo-1,2,3,4-四氢喹啉-3-羧酸酯的便捷合成
DOI：
10.1246/bcsj.76.1257
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发表时间：
2003
影响因子：
4
通讯作者：
H. Konishi
中科院分区：
文献类型：
--
作者：
K. Kobayashi;Ryoji Nakahashi;M. Mano;Osamu Morikawa;H. Konishi
已发现在2-（甲氨基）苯甲酸甲酯和α，β-不饱和羧酸酯之间的镁酰胺诱导的连续共轭加成/Claisen型缩合提供了方便的4-羟基-1，2-二氢喹啉-3-羧酸酯衍生物和4-氧代-1，2，3，4-四氢喹啉-3-羧酸酯。
A magnesium amide-induced sequential conjugate addition/Claisen-type condensation between methyl 2-(methylamino)benzoate and α,β-unsaturated carboxylates has been found to provide convenient access to 4-hydroxy-1,2-dihydroquinoline-3-carboxylate derivatives and 4-oxo-1,2,3,4-tetrahydroquinoline-3-carboxylates.