Stable isotope ratios of carbon, nitrogen and selenium concentration in the scalp hair of Crohn's disease patients who ingested the elemental diet Elental ?
Stable isotope ratios of carbon, nitrogen and selenium concentration in the scalp hair of Crohn's disease patients who ingested the elemental diet Elental ?
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摄入元素饮食 Elental 的克罗恩病患者头皮中碳、氮和硒浓度的稳定同位素比率？
DOI：
10.1002/rcm.8296
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发表时间：
2018
影响因子：
2
通讯作者：
Endo Tetsuya
中科院分区：
文献类型：
--
作者：
Ogasawara Hideki;Hayasaka Moriaki;Maemoto Atsuo;Furukawa Shigeru;Ito Takahiro;Kimura Osamu;Endo Tetsuya
在日本，作为克罗恩病（CD）患者的营养补充剂，广泛使用的元素饮食。Elental®含有氨基酸作为氮源，不含硒（Se），Elental®的δ 13 C和δ 15 N值分别明显高于和低于正常diet.MethodsWe比较了CD患者的δ 13 C和δ 15 N值和头皮头发中的Se浓度与正常饮食的对照受试者，并估计了Elental®作为补充剂摄入的量。分别使用同位素比质谱法（IRMS）和电感耦合等离子体质谱法（ICP-MS）定量δ 13 C和δ 15 N值以及Se浓度。（p<0.05），δ 15 N值降低（p<0.05），但不影响正常人的生活。结论通过δ 13 C和δ 15 N值可以估算Elental®的摄入量在CD患者的头发里此外，δ 13 C和δ 15 N值可预测女性患者的缺硒情况。
RationaleElental®is an elemental diet widely used as a nutritional supplement for Crohn's disease (CD) patients in Japan. Elental®contains amino acids as nitrogen sources and does not contain selenium (Se), and the δ13C and δ15N values of Elental®are markedly higher and lower, respectively, than those of a normal diet.MethodsWe compared the δ13C and δ15N values and Se concentration in the scalp hair of CD patients with those of control subjects who ate a regular diet, and estimated the amount of Elental®ingested as a supplement. The δ13C and δ15N values and the Se concentrations were quantified using isotope ratio mass spectrometry (IRMS) and inductively coupled plasma mass spectrometry (ICP‐MS), respectively.ResultsAn increase in Elental®ingestion increased the δ13C value in the hair of CD patients (p<0.05), while it reduced the δ15N value (p<0.05) and tended to reduce the Se concentration in female patients.ConclusionsThe amount of Elental®ingested could be estimated by the δ13C and δ15N values in the hair of CD patients. Furthermore, the Se deficiency in female patients may be predicted from the δ13C and δ15N values.