Hydrogen-bonded silicene nanosheets of engineered bandgap and selective degradability for photodynamic therapy
Hydrogen-bonded silicene nanosheets of engineered bandgap and selective degradability for photodynamic therapy
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用于光动力治疗的具有工程带隙和选择性降解性的氢键硅烯纳米片
DOI：
10.1016/j.biomaterials.2021.121172
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发表时间：
2021-10-13
期刊：
影响因子：
14
通讯作者：
Shi, Jianlin
中科院分区：
文献类型：
--
作者：
Xu, Deliang;Lin, Han;Shi, Jianlin
硅是一种具有高度生物相容性且普遍存在于生命系统中的化学元素，在生物医学领域具有巨大的应用潜力。然而，硅基纳米材料，如二氧化硅和多孔硅，由于缺乏硅的固有功能，在很大程度上仅限于作为输送系统的载体。这项工作提出了一个二维（2D）氢键硅烯（h -硅烯）纳米系统的简单构建，该系统具有可调的带隙和选择性降解性，可以通过氢原子的表面共价修饰轻松地用于肿瘤特异性光动力治疗。简而言之，h -硅烯纳米片材料在正常中性组织中可选择性降解，但在轻度酸性肿瘤微环境（TME）中相当稳定，从而实现有效的光动力治疗（PDT）。这种具有可调带隙和肿瘤选择性降解性的二维氢键硅纳米体系为多功能二维硅基生物材料在癌症和其他疾病的诊断和治疗中的应用提供了新的范例。
Silicon, a highly biocompatible and ubiquitous chemical element in living systems, exhibits great potentials in biomedical applications. However, the silicon-based nanomaterials such as silica and porous silicon have been largely limited to only serving as carriers for delivery systems, due to the lack of intrinsic functionalities of silicon. This work presents the facile construction of a two-dimensional (2D) hydrogen-bonded silicene (H-silicene) nanosystem which is highlighted with tunable bandgap and selective degradability for tumor-specific photodynamic therapy facilely by surface covalent modification of hydrogen atoms. Briefly, the H-silicene nanosheet material is selectively degradable in normal neutral tissues but rather stable in the mildly acidic tumor microenvironment (TME) for achieving efficient photodynamic therapy (PDT). Such a 2D hydrogen-bonded silicene nanosystem featuring the tunable bandgap and tumor-selective degradability provides a new paradigm for the application of multi-functional two-dimensional silicon-based biomaterials towards the diagnosis and treatments of cancer and other diseases.