PC3 is involved in the shift from proliferation to differentiation and maturation in spiral ganglion neurons
PC3 is involved in the shift from proliferation to differentiation and maturation in spiral ganglion neurons
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DOI：
10.1097/wnr.0b013e328332c4d7
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发表时间：
2010-01-27
期刊：
影响因子：
1.7
通讯作者：
Yumoto, Eiji
中科院分区：
文献类型：
--
作者：
Hayashida, Momoko;Minoda, Ryosei;Yumoto, Eiji
PC3 是抗增殖基因 BTG/Tob 家族的成员。在这里，我们报告了胚胎第 16 天 (E16) 和 20 (E20) 以及出生后第 4 天 (P4) 和 7 (P7) 大鼠耳蜗螺旋神经节神经元中 PC3 蛋白表达的分析结果。在E11 6和E20的神经节神经元细胞质中观察到PC3表达，并且该蛋白已通过P4转位至细胞核。 Ki-67（一种由分裂细胞表达的核抗原）的表达在 E16 和 E20 的神经节神经元中检测到，但在 P4 或 P7 时未检测到。这些结果表明PC3参与大鼠耳蜗神经节神经元从增殖到分化和成熟的转变。 NeuroReport 21:90-93 (C) 2010 Wolters Kluwer Health 垂直条 Lippincott Williams & Wilkins。
PC3 is a member of the BTG/Tob family of antiproliferative genes. Here, we report the results of an analysis of PC3 protein expression in spiral ganglion neurons of the rat cochlea at embryonic days 16 (E16) and 20 (E20), and postnatal days 4 (P4) and 7 (P7). PC3 expression was observed in the cytoplasm of ganglion neurons at Ell 6 and E20, and this protein had translocated to the nucleus by P4. The expression of Ki-67, a nuclear antigen expressed by dividing cells, was detected in ganglion neurons at E16 and E20, but not at P4 or P7. These results suggest that PC3 is involved in the shift from proliferation to differentiation and maturation in the ganglion neurons of the rat cochlea. NeuroReport 21:90-93 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.