A comparative genomics multitool for scientific discovery and conservation.
A comparative genomics multitool for scientific discovery and conservation.
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DOI：
10.1038/s41586-020-2876-6
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发表时间：
2020-11
期刊：
影响因子：
64.8
通讯作者：
Zoonomia Consortium
中科院分区：
文献类型：
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作者：
Zoonomia Consortium
Zoonomia项目正在研究真兽目哺乳动物共有和专门特征的基因组学。在这里，我们提供了131个物种的基因组组件，其中所有，但9个是以前的特点，并描述了一个全基因组比对240种相当大的系统发育多样性，包括代表超过80%的哺乳动物家庭。我们发现，遗传多样性减少的区域在灭绝风险高的物种中更丰富，在高分辨率下识别进化选择的信号，并从个体参考基因组中提供见解。通过优先考虑系统发育多样性和快速无限制地提供数据，Zoonomia项目旨在支持生物发现，医学研究和生物多样性保护。来自Zoonomia项目的240种遗传多样的真兽目哺乳动物的全基因组比对-包括131种以前未表征的物种-提供了支持生物发现，医学研究和保护的数据。
The Zoonomia Project is investigating the genomics of shared and specialized traits in eutherian mammals. Here we provide genome assemblies for 131 species, of which all but 9 are previously uncharacterized, and describe a whole-genome alignment of 240 species of considerable phylogenetic diversity, comprising representatives from more than 80% of mammalian families. We find that regions of reduced genetic diversity are more abundant in species at a high risk of extinction, discern signals of evolutionary selection at high resolution and provide insights from individual reference genomes. By prioritizing phylogenetic diversity and making data available quickly and without restriction, the Zoonomia Project aims to support biological discovery, medical research and the conservation of biodiversity. A whole-genome alignment of 240 phylogenetically diverse species of eutherian mammal—including 131 previously uncharacterized species—from the Zoonomia Project provides data that support biological discovery, medical research and conservation.