Global patterns of isolation by distance based on genetic and morphological data
Global patterns of isolation by distance based on genetic and morphological data
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DOI：
10.1353/hub.2004.0060
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发表时间：
2004-08-01
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影响因子：
--
通讯作者：
Relethford, JH
中科院分区：
文献类型：
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作者：
Relethford, JH
距离隔离模型预测，种群间的遗传相似性将随着地理距离的增加而呈指数下降，因为地理距离对基因流动速率的限制作用。许多人类种群的研究已经将距离隔离模型应用于有限地理区域内当地种群之间的遗传变异。但在全球一级这样做的国家很少，而且这些国家使用的模型和分析方法也不同。我使用红细胞多态性，微卫星DNA标记的数据评估世界各地人群之间的遗传变异。和颅骨测量特征隔离距离模型提供了一个很好的适合所有三个数据集的地理距离类内的遗传相似性的平均水平，距离衰减率是相同的。研究结果表明，在不同的遗传和形态学数据中，可以检测到由地理距离介导的全球基因流动的共同模式。另一种解释是，遗传相似性和地理距离之间的对应关系反映了人类物种从非洲扩散出去的历史。
The isolation-by-distance model predicts that genetic similarity between populations will decrease exponentially as the geographic distance between them increases, because of the limiting effect of geographic distance on rates of gene flow. Many studies of human populations have applied the isolation-by-distance model to genetic variation between local populations in a limited geographic area. but few have done so on a global level, and these few used different models and analytical methods. I assess genetic variation between human populations across the World using data on red blood cell polymorphisms, microsatellite DNA markers. and craniometric traits. The isolation-by-distance model provides an excellent fit to average levels of genetic similarity within geographic distance classes for all three data sets, and the rate of distance decay is the same in all three. The se results suggest that a common pattern of global gene flow mediated by geographic distance is detectable in diverse genetic and morphological data. An alternative explanation is that the correspondence between genetic similarity and geographic distance reflects the history of dispersal of the human species out of Africa.