Zinc-induced hyperleptinemia relates to the amelioration of sucrose-induced obesity with zinc repletion
Zinc-induced hyperleptinemia relates to the amelioration of sucrose-induced obesity with zinc repletion
复制标题
DOI：
10.1038/oby.2000.65
复制
发表时间：
2000-10-01
期刊：
影响因子：
--
通讯作者：
Lin, PY
中科院分区：
文献类型：
--
作者：
Chen, MD;Lin, PY
目的：膳食补锌可改善蔗糖性肥胖。锌和瘦素之间的正相关关系最近被注意到，两者都被认为是控制食欲的重要介质。在这项研究中，我们研究了锌补充对蔗糖诱导肥胖的改善是否取决于循环瘦素水平的变化。研究方法和步骤：在半纯化饮食的基础上，给予32%的蔗糖溶液诱导肥胖小鼠，根据其饮用水中是否添加20毫克/升的锌，将其分为两组。结果：正如预期的那样，与单独给糖的小鼠相比，蔗糖诱导肥胖的小鼠出现了高血糖、高胰岛素血症、高甘油三酯血症、高瘦素血症和低锌血症。补充锌后，蔗糖喂养的肥胖小鼠体重增加、体脂含量、食物和蔗糖摄入量有降低的趋势，但没有统计学意义。然而，一些血清变量（葡萄糖，胰岛素，甘油三酯和锌），在蔗糖喂养的肥胖小鼠锌处理接近于那些只给饮食的小鼠的值。此外，蔗糖喂养的肥胖小鼠补充锌后血清瘦素值最高。讨论：本研究表明，补锌对蔗糖性肥胖的改善可能部分归因于矿物质引起的高瘦素血症。
Objective: Dietary zinc repletion can ameliorate sucrose-induced obesity. A positive correlation between zinc and leptin has been recently noted, and both are known as important mediators in appetite control. In this study, we examined whether the reported amelioration of sucrose-induced obesity by zinc repletion was consequent on the changes in circulating leptin levels.Research Methods and Procedures: Mice with obesity that was induced by giving a 32% sucrose solution in addition to a semipurified diet were divided into two groups based on whether they had 20 mg/liter zinc supplementation in their drinking water.Results: As expected, the mice with sucrose-induced obesity had hyperglycemia, hyperinsulinemia, hypertriglyceridemia, hyperleptinemia, and hypozincemia when compared with the mice given the diet alone. Body weight gain, body fat content, and food and sucrose intake tended to decrease but not with statistical significance in sucrose-fed obese mice with zinc supplementation. Nevertheless, some serum variables (glucose, insulin, triglycerides, and zinc) in sucrose-fed obese mice with zinc treatment were approximate to those values of the mice given the diet alone. Moreover, sucrose-fed obese mice with zinc supplementation had the highest serum Values of leptin.Discussion: This study indicates that the amelioration of sucrose-induced obesity by zinc repletion may be partly attributable to the hyperleptinemia induced by the mineral.