Measurement of relative biological effectiveness of protons in human cancer cells using a laser-driven quasimonoenergetic proton beamline
Measurement of relative biological effectiveness of protons in human cancer cells using a laser-driven quasimonoenergetic proton beamline
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DOI：
10.1063/1.3551623
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发表时间：
2011-01-31
影响因子：
4
通讯作者：
Kondo, K.
中科院分区：
文献类型：
--
作者：
Yogo, A.;Maeda, T.;Kondo, K.
用激光驱动的准单能质子辐照人类癌细胞。5 × 10（19）W/cm（2）水平的激光脉冲强度为质子提供了源和加速场，随后由四个能量选择性偶极磁体传输。传输线提供2.25 MeV的质子，能量扩展为0.66 MeV，聚束持续时间为20 ns。在剂量水平高达8戈伊的质子照射后，用集落形成测定法测量来自人唾液腺肿瘤的体外细胞的存活分数，其中对于1 Hz重复照射，单束剂量率为1 × 10（7）戈伊/s，有效剂量率为0.2戈伊/s。使用线性能量转移为17.1 keV/μ m的质子，在10%存活分数下测得的相对生物学有效性为1.20 +/- 0.11。(C)2011年美国物理学会。[doi：10.1063/1.3551623]
Human cancer cells are irradiated by laser-driven quasimonoenergetic protons. Laser pulse intensities at the 5 x 10(19) W/cm(2) level provide the source and acceleration field for protons that are subsequently transported by four energy-selective dipole magnets. The transport line delivers 2.25 MeV protons with an energy spread of 0.66 MeV and a bunch duration of 20 ns. The survival fraction of in vitro cells from a human salivary gland tumor is measured with a colony formation assay following proton irradiation at dose levels of up to 8 Gy, for which the single bunch dose rate is 1 x 10(7) Gy/s and the effective dose rate is 0.2 Gy/s for 1 Hz repetition of irradiation. Relative biological effectiveness at the 10% survival fraction is measured to be 1.20 +/- 0.11 using protons with a linear energy transfer of 17.1 keV/mu m. (C) 2011 American Institute of Physics. [doi: 10.1063/1.3551623]