It takes a tissue to make a tumor: Epigenetics, cancer and the microenvironment
It takes a tissue to make a tumor: Epigenetics, cancer and the microenvironment
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DOI：
10.1023/a:1011317009329
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发表时间：
2001-04-01
影响因子：
2.5
通讯作者：
Barcellos-Hoff, MH
中科院分区：
文献类型：
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作者：
Barcellos-Hoff, MH
正常组织如何限制癌症的发展？这篇综述讨论了正常细胞有效地限制恶性行为的证据，以及这种组织力量必须被征服才能建立肿瘤。电离辐射的作用将具体讨论促进从癌前病变向肿瘤生长过渡的微环境的破坏。与高度不可预测的基因突变不同，正常细胞对辐射损伤的反应遵循与伤口愈合和其他损伤反应类似的表观遗传程序。我们的假设是，照射组织中微环境的持续破坏会损害其抑制癌变的能力。
How do normal tissues limit the development of cancer? This review discusses the evidence that normal cells effectively restrict malignant behavior, and that such tissue forces must be subjugated to establish a tumor. The action of ionizing radiation will be specifically discussed regarding the disruption of the microenvironment that promotes the transition from preneoplastic to neoplastic growth. Unlike the highly unpredictable nature of genetic mutations, the response of normal cells to radiation damage follows an epigenetic program similar to wound healing and other damage responses. Our hypothesis is that the persistent disruption of the microenvironment in irradiated tissue compromises its ability to suppress carcinogenesis.