Behavioral effects of acute and chronic fluoxetine in Wistar-Kyoto rats
Behavioral effects of acute and chronic fluoxetine in Wistar-Kyoto rats
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DOI：
10.1016/s0031-9384(98)00298-4
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发表时间：
1999-09-01
影响因子：
2.9
通讯作者：
Sanger, DJ
中科院分区：
文献类型：
--
作者：
Griebel, G;Cohen, C;Sanger, DJ
以前曾报道，Wistar-Kyoto（WKY）大鼠可能是有用的，在应激相关疾病的生物学机制的研究。在本研究中，WKY急性或慢性（每天一次腹腔注射，持续22-24天）使用选择性5-HT再摄取抑制剂和临床有效的抗抑郁药和抗焦虑药氟西汀（5和20 mg/kg），并在注射后不同时间（30、60 min或24 h）暴露于强迫游泳试验（FST）和高架十字迷宫（ESTA）。在FST中，无论治疗如何，WKY对氟西汀均无应答。在研究中，当动物在给药后24小时进行试验时，急性氟西汀（20 mg/kg）产生了抗焦虑样作用，但在给药后30分钟未产生。积极的影响，在无影响的活动措施（总和闭臂条目）的情况下，在传统的（开臂活动）和行为学（风险评估）的措施，是显而易见的。在长期氟西汀治疗后未观察到抗焦虑样活性的证据。这些结果表明，WKY大鼠在FST中对氟西汀治疗具有耐药性，而当动物在测试前24小时接受单次氟西汀激发时，它们的行为可能会发生改变。总的来说，这些发现几乎没有证据表明WKY大鼠可能代表了一个有效的模型，压力相关的疾病。(C)1999 Elsevier Science Inc.
It has been previously reported that Wistar-Kyoto (WKY) rats may be useful in the study of the biological mechanisms involved in stress-related disorders. In the present study, WKY were treated acutely or chronically (one daily i.p. injection for 22-24 days) with the selective 5-HT reuptake inhibitor and clinically effective antidepressant and anxiolytic fluoxetine (5 and 20 mg/kg) and exposed to the forced swimming test (FST) and to the elevated plus-maze (EPM) at different times postinjection (30, 60, min or 24 h). In the FST, WKY failed to respond to fluoxetine, regardless of treatment. In the EPM:, acute fluoxetine (20 mg/kg) produced anxiolytic-like effects when animals were tested 24 h, but not 30 min after drug administration. Positive effects in the EPM were evident on both conventional (open-arm activity) and ethological (risk assessment) measures in the absence of effect on activity measures (total and closed-arm entries). No evidence for anxiolytic-like activity was observed following chronic fluoxetine. These results indicate that WKY rats are resistant to fluoxetine treatment in the FST, while their behavior may be modified in the EPM when animals received a single fluoxetine challenge 24 h before testing. Overall, these findings provided little evidence that WKY rats may represent a valid model of stress-related disorders. (C) 1999 Elsevier Science Inc.