Long-term stability of visual pattern selective responses of monkey temporal lobe neurons.
Long-term stability of visual pattern selective responses of monkey temporal lobe neurons.
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DOI：
10.1371/journal.pone.0008222
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发表时间：
2009-12-09
期刊：
影响因子：
3.7
通讯作者：
Logothetis NK
中科院分区：
文献类型：
--
作者：
Bondar IV;Leopold DA;Richmond BJ;Victor JD;Logothetis NK
灵长类动物下颞叶（IT）皮层中的许多神经元对复杂的、通常有意义的刺激（如面部和物体）有选择性地做出反应。一个重要的未解之谜是，这种被认为来自经验依赖性可塑性的反应选择性是否每天都在维持，或者单个细胞的角色是否根据自然视觉的饮食不断重新分配。我们使用长期植入两只猴子颞叶的微丝电极来解决这个问题，通常允许我们在几天内监测单个神经元的活动。我们发现，神经元保持其选择性的反应幅度和模式的尖峰定时在一个大的视觉图像的整个期间的稳定信号隔离从同一个细胞，有时超过两个星期。这些结果表明，刺激选择性的反应在IT是稳定的，在几天和几周的视觉体验。
Many neurons in primate inferotemporal (IT) cortex respond selectively to complex, often meaningful, stimuli such as faces and objects. An important unanswered question is whether such response selectivity, which is thought to arise from experience-dependent plasticity, is maintained from day to day, or whether the roles of individual cells are continually reassigned based on the diet of natural vision. We addressed this question using microwire electrodes that were chronically implanted in the temporal lobe of two monkeys, often allowing us to monitor activity of individual neurons across days. We found that neurons maintained their selectivity in both response magnitude and patterns of spike timing across a large set of visual images throughout periods of stable signal isolation from the same cell that sometimes exceeded two weeks. These results indicate that stimulus-selectivity of responses in IT is stable across days and weeks of visual experience.
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影响因子：
64.8
作者：
Afraz, Seyed-Reza;Kiani, Roozbeh;Esteky, Hossein
通讯作者：
Esteky, Hossein
DOI：
10.1073/pnas.211431098
发表时间：
2001-10-09
影响因子：
11.1
作者：
Messinger, A;Squire, LR;Albright, TD
通讯作者：
Albright, TD
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作者：
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通讯作者：
Giese, Martin A.
影响因子：
2.5
作者：
Jagadeesh, B;Chelazzi, L;Desimone, R
通讯作者：
Desimone, R