Total eosinophil counts in the management of bronchial asthma.
Total eosinophil counts in the management of bronchial asthma.
复制标题
支气管哮喘治疗中的嗜酸性粒细胞总数。
DOI：
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发表时间：
1975
影响因子：
158.5
通讯作者：
A. V. Kessel
中科院分区：
文献类型：
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作者：
B. Horn;E. Robin;J. Theodore;A. V. Kessel
研究哮喘患者的总嗜酸性粒细胞计数，以确定其在激素依赖性哮喘的诊断和治疗中的有用性。计数平均为122 ± 74（S.D.）每mm-3（65名未经治疗的正常受试者）和43 ± 22每mm-3（6名泼尼松治疗的正常受试者）。52例活动性支气管哮喘患者表现出显著的嗜酸性粒细胞增多（停用时大于350/mm-3，使用类固醇时大于85/mm-3），表明嗜酸性粒细胞增多是支气管哮喘的重要诊断特征。在14例患者（60次观察）中，计数显示与比气道传导率显著负相关-r = 0.74，p <0.001-以及与各种其他支气管动力学和肺体积测量值显著负相关，表明总嗜酸性粒细胞计数反映哮喘活动，并有助于调节类固醇剂量和早期检测急性发作。
Total eosinophil counts were investigated in asthmatic patients to determine their usefulness in the diagnosis and management of steroid-dependent asthma. Counts averaged 122 plus or minus 74 (S.D.) per mm-3 (65 untreated normal subjects) and 43 plus or minus 22 per mm-3 (six prednisone-treated normal subjects). Fifty-two patients with active bronchial asthma showed significant eosinophilia (greater than 350/mm-3 off and greater than 85/mm-3 on steroids), suggesting that eosinophilia is an important diagnostic feature of bronchial asthma. In 14 patients (60 observations), the counts showed significant inverse correlation with specific airway conductance--r equals 0.74, p less than 0.001--and with a variety of other measurements of bronchial dynamics and lung volumes, suggesting that the total eosinophil count reflects asthmatic activity and is useful for regulating steroid dosage and for early detection of exacerbations.