Resident Neural Stem Cells Restrict Tissue Damage and Neuronal Loss After Spinal Cord Injury in Mice
Resident Neural Stem Cells Restrict Tissue Damage and Neuronal Loss After Spinal Cord Injury in Mice
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DOI：
10.1126/science.1242576
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发表时间：
2013-11-01
期刊：
影响因子：
56.9
通讯作者：
Frisen, Jonas
中科院分区：
文献类型：
--
作者：
Sabelstrom, Hanna;Stenudd, Moa;Frisen, Jonas
中枢神经系统损伤伴瘢痕形成。由于疤痕是由几种不同类型的细胞形成的，这可能会限制损伤，但也会抑制轴突的再生，因此很难确定疤痕的确切作用。我们发现，神经干细胞衍生的星形胶质细胞形成的瘢痕是限制脊髓损伤后病变继发性扩大和进一步轴突损失的必要条件。此外，神经干细胞后代对病变附近神经元的存活具有神经营养作用。神经胶质疤痕有一种独特的成分，来源于常驻的神经干细胞，是维持受伤脊髓完整性所必需的。
Central nervous system injuries are accompanied by scar formation. It has been difficult to delineate the precise role of the scar, as it is made by several different cell types, which may limit the damage but also inhibit axonal regrowth. We show that scarring by neural stem cell-derived astrocytes is required to restrict secondary enlargement of the lesion and further axonal loss after spinal cord injury. Moreover, neural stem cell progeny exerts a neurotrophic effect required for survival of neurons adjacent to the lesion. One distinct component of the glial scar, deriving from resident neural stem cells, is required for maintaining the integrity of the injured spinal cord.