Cerebrovascular complications of diabetes: focus on cognitive dysfunction.
Cerebrovascular complications of diabetes: focus on cognitive dysfunction.
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DOI：
10.1042/cs20160397
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发表时间：
2016-10-01
期刊：
影响因子：
--
通讯作者：
Ergul A
中科院分区：
文献类型：
--
作者：
Hardigan T;Ward R;Ergul A
在过去的30年里，美国的糖尿病发病率增加了一倍多，预计到2030年，全球发病率将翻一番。认知障碍一直与糖尿病有关，糖尿病会恶化患者的生活质量。神经元与周围血管系统的结构和功能的相互作用对于中枢神经系统的正常功能至关重要，包括与学习和记忆有关的区域。因此，在这篇综述中，我们探讨了患者和实验模型中的认知障碍，重点是与血管功能障碍和结构变化的联系。最后，我们提出了先天性免疫--介导的炎症在糖尿病神经血管改变中的作用。
The incidence of diabetes has more than doubled in the United States in the last 30 years and the global disease rate is projected to double by 2030. Cognitive impairment has been associated with diabetes, worsening quality of life in patients. The structural and functional interaction of neurons with the surrounding vasculature is critical for proper function of the central nervous system including domains involved in learning and memory. Thus, in this review we explore cognitive impairment in patients and experimental models, focusing on links to vascular dysfunction and structural changes. Lastly, we propose a role for the innate immunity--mediated inflammation in neurovascular changes in diabetes.