Radiosensitizing hypoxic cells with new 3-nitro-1,2,4-triazole derivatives in vitro and in vivo.
Radiosensitizing hypoxic cells with new 3-nitro-1,2,4-triazole derivatives in vitro and in vivo.
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在体外和体内用新型 3-硝基-1,2,4-三唑衍生物对缺氧细胞进行放射增敏。
DOI：
10.1248/cpb.37.1951
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发表时间：
1989
影响因子：
1.7
通讯作者：
K. Sasai
中科院分区：
文献类型：
--
作者：
Y. Nagao;S. Sano;M. Ochiai;K. Fuji*;S. Nishimoto;T. Kagiya;C. Murayama;T. Mori;Y. Shibamoto;K. Sasai
合成了新的3-硝基-1，2，4-三唑（3-NTR）的区域异构体衍生物4a-f和5a-f，用于开发新的乏氧癌细胞放射增敏剂。N（2）-取代的3-NTR衍生物5a-f在体外（中国仓鼠V79细胞）比N（1）-取代的3-NTR衍生物4a-f对乏氧细胞有更强的放射增敏作用，但在体内（接种到C3 H/He小鼠中的SCCVII癌细胞）它们的放射增敏作用较弱。
The new regioisomer derivatives 4a-f and 5a-f of 3-nitro-1,2,4-triazole (3-NTR) were synthesized for the development of new radiosensitizers of hypoxic cancer cells for radiotherapy. N(2)-Substituted 3-NTR derivatives 5a-f were stronger radiosensitizers of hypoxic cells in vitro (Chinese hamster V79 cells) than N(1)-substituted 3-NTR derivatives 4a-f, but in vivo they were weaker (SCCVII carcinoma cells inoculated into C3H/He mouse).