Natural anthraquinones probed as Type I and Type II photosensitizers:: singlet oxygen and superoxide anion production
Natural anthraquinones probed as Type I and Type II photosensitizers:: singlet oxygen and superoxide anion production
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DOI：
10.1016/j.jphotobiol.2004.09.009
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发表时间：
2005-01-14
影响因子：
5.4
通讯作者：
Cabrera, JL
中科院分区：
文献类型：
--
作者：
Montoya, SCN;Comini, LR;Cabrera, JL
研究了6种蒽醌类化合物的光敏性，它们是：soranjidiol（1），soranjidiol-1-methyl ether（2），rubiadin（3），rubiadin-1-methyl ether（4），damnacanthal（5）和damnacanthol（6）。F.（Rubiaceae）进行了研究。通过体外光生物学和生物物理学方法，确定了这些代谢物能够产生的光敏化类型。而光敏化产生的超氧阴离子自由基（O-2（.-））(Type I）在白细胞悬浮液中进行评价，在有机溶液中检查单线态分子氧（102）的产生（II型）。此外，还测定了O-1（2）（Phi）在氯仿中的量子产率，确定了4只作为I型光敏剂。相比之下，其他的AQs通过两种类型的机制起作用，其中5个表现出O-1的最大Phi（2）。(C)2004 Elsevier B. V.保留所有权利。
The pholosensitizing properties of six anthraquinones (AQs): soranjidiol (1), soranjidiol-1-methyl ether (2), rubiadin (3), rubiadin-l-methyl ether (4), damnacanthal (5) and damnacanthol (6), isolated from leaves and stems of Heterophyllaea pustulata Hook. f. (Rubiaceae) were studied. By means of photobiological and photophysical methods in vitro, the type of photosensitization that these metabolites are capable of producing was determined. Whereas the photosensitized generation of superoxide anion radical (O-2(.-)) (Type I) was evaluated in leukocyte suspensions, singlet molecular oxygen (102) production (Type II) was examined in organic solution. In addition, the quantum yield of O-1(2) (Phi) in chloroform was measured for those AQs that generate it. It was established that 4 behaves exclusively as a Type I photosensitizer. By contrast, the others AQs act by both types of mechanisms, among which 5 showed the largest Phi of O-1(2). (C) 2004 Elsevier B.V. All rights reserved.