The Effect of Aging on Aerosol Bolus Deposition in the Healthy Adult Lung: A 19-Year Longitudinal Study.
The Effect of Aging on Aerosol Bolus Deposition in the Healthy Adult Lung: A 19-Year Longitudinal Study.
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DOI：
10.1089/jamp.2019.1566
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发表时间：
2020-06
影响因子：
3.4
通讯作者：
C. Darquenne;G. Prisk
中科院分区：
文献类型：
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作者：
C. Darquenne;G. Prisk
背景：虽然已经认识到周围肺结构和通风的异质性随年龄变化，但年龄对健康成人肺内气溶胶沉积的影响在很大程度上是未知的。方法：对4名健康受试者进行连续雾化吸入治疗，持续时间分别为0、9、15、19年。对于每个系列，吸入1μm颗粒的团注，渗透体积(Vp)从200到1200毫升。计算气溶胶团沉积(DE)、离散度(H)和模式漂移(MS)，并计算这些参数随VP增加的速率(SLOPE-DE、SLOPE-H和SLOPE-MS)。结果：SLOPE-DE从0.040岁时的0.040±0.014(均值±标准差)增加到19岁时的0.069±0.007%/mL(p=0.02)，而浅层DE无显著差异(Vp=200mL；0岁时为14%±4%，19岁时为15%±7%，p=0.25)。年龄对SLOPE-H(0岁时0.44±0.05对19岁时0.47±0.09毫升/毫升，p=0.6)或浅层弥散(0岁时192±36毫升对19岁时220±54毫升，p=0.2)均无显著影响。随着年龄的增长，SLOPE-MS的负值显著增加(0岁时为-0.096±0.044，19岁时为-0.171±0.027毫升/毫升，p=0.001)，而浅层MS无显著差异(0岁时为12±10毫升，19岁时为7±15毫升，P=0.001)。结论：这些数据提示：(1)健康人肺的周围沉积随着年龄的增长而增加，这可能是由于闭合体积随年龄增加所致；(2)健康成人肺的力学特性随年龄的变化是一致的；(3)MS斜率的大小随年龄的增长而显著增加，可能是由于伴随着周围沉积的增加和血流序列的改变。
Background: While it is recognized that peripheral lung structure and ventilation heterogeneity change with age, the effects of age on aerosol deposition in the healthy adult lung is largely unknown. Methods: A series of aerosol bolus inhalations were repeatedly performed in four healthy subjects over a period of 19 years (years = 0, 9, 15 and 19). For each series, a bolus of 1 μm particles was inhaled at penetration volumes (Vp) ranging from 200 to 1200 mL. Aerosol bolus deposition (DE), dispersion (H), and mode shift (MS) were calculated along with the rate of increase in these parameters with increasing Vp (slope-DE, slope-H, and slope-MS). Results: Slope-DE significantly increased from 0.040 ± 0.014 (mean ± standard deviation) at year 0 to 0.069 ± 0.007%/mL at year 19 (p = 0.02) with no significant difference in DE at shallow depth (Vp = 200 mL; 14% ± 4% at year 0 vs. 15% ± 7% at year 19, p = 0.25). There was no significant effect of age on either slope-H (0.44 ± 0.05 at year 0 vs. 0.47 ± 0.09 mL/mL at year 19, p = 0.6) or dispersion at shallow depth (192 ± 36 mL at year 0 vs. 220 ± 54 mL at year 19, p = 0.2). Slope-MS became significantly more negative with increasing age (-0.096 ± 0.044 at year 0 vs. -0.171 ± 0.027 mL/mL at year 19, p = 0.001) with no significant difference in MS at shallow depth (12 ± 10 at year 0 vs. 7 ± 15 mL at year 19, p = 0.3). Conclusions: These data suggest that (1) peripheral deposition increases with aging in the healthy lung, likely as a result of increasing closing volume with age; (2) alterations in the mechanical properties of healthy adult lungs with age occur uniformly; and (3) the significant increase in the magnitude of MS-slope with age is likely due to the concomitant increase in peripheral deposition and possible alterations in flow sequencing.