TRPA1: Acrolein meets its target.
TRPA1: Acrolein meets its target.
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DOI：
10.1016/j.taap.2017.03.007
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发表时间：
2017-06-01
影响因子：
3.8
通讯作者：
Jordt SE
中科院分区：
文献类型：
--
作者：
Achanta S;Jordt SE
Two papers in this issue of Toxicology and Applied Pharmacology reveal that the sensory irritant receptor, Transient Receptor Potential Ankyrin 1 (TRPA1), plays a key role in the morbidity and mortality caused by inhalation of acrolein, the major electrophile in smoke from fires, tobacco and in automobile exhaust (Conklin et al., 2016, Kurhanewicz et al., 2016). Animals deficient in TRPA1, or treated with a TRPA1 inhibitor, were resistant to acrolein-induced cardiac arrhythmia and pulmonary injury and survived severely toxic acrolein exposures at higher rates than wild-type mice. Recognizing the multiple targets and injury mechanisms previously proposed for this reactive aldehyde, these are remarkable findings pointing towards an unexpected role of chemosensory reflex and homeostatic mechanisms in toxicological injuries.
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