High-density information storage in an absolutely defined aperiodic sequence of monodisperse copolyester
High-density information storage in an absolutely defined aperiodic sequence of monodisperse copolyester
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DOI：
10.1038/s41467-019-13952-2
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发表时间：
2020-01-07
影响因子：
16.6
通讯作者：
Kim, Kyoung Taek
中科院分区：
文献类型：
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作者：
Lee, Jung Min;Koo, Mo Beom;Kim, Kyoung Taek
在聚合物化学中，如何合成一种由大量离散的、化学性质不同的单体以绝对确定的非周期序列组成的聚合物仍然是一个挑战。由于逐步添加单个单体以获得高分子量的困难，合成在很大程度上局限于具有有限数量重复单元的低聚物。在这里，我们报告了-羟基酸共聚物，聚（苯基乳酸-共乳酸）（PcL），通过交叉收敛的方法建立从四对单体为组成单元。我们提出的方法允许在最小数量的化学计量量的试剂偶联步骤中可扩展地合成序列定义的PcL。数字信息可以存储在PcL的非周期序列中，该序列可以通过质谱测序完全检索为二进制代码。PcL的信息存储密度（bit/Da）比DNA高50%，并可通过调节分子量（约38 kDa）提高PcL的存储容量。
Synthesis of a polymer composed of a large discrete number of chemically distinct monomers in an absolutely defined aperiodic sequence remains a challenge in polymer chemistry. The synthesis has largely been limited to oligomers having a limited number of repeating units due to the difficulties associated with the step-by-step addition of individual monomers to achieve high molecular weights. Here we report the copolymers of alpha-hydroxy acids, poly (phenyllactic-co-lactic acid) (PcL) built via the cross-convergent method from four dyads of monomers as constituent units. Our proposed method allows scalable synthesis of sequence-defined PcL in a minimal number of coupling steps from reagents in stoichiometric amounts. Digital information can be stored in an aperiodic sequence of PcL, which can be fully retrieved as binary code by mass spectrometry sequencing. The information storage density (bit/Da) of PcL is 50% higher than DNA, and the storage capacity of PcL can also be increased by adjusting the molecular weight (similar to 38 kDa).