Sleep continuity is positively correlated with sleep duration in laboratory nighttime sleep recordings.
Sleep continuity is positively correlated with sleep duration in laboratory nighttime sleep recordings.
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DOI：
10.1371/journal.pone.0175504
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Rapoport DM
中科院分区：
文献类型：
--
作者：
Kishi A;Van Dongen HP;Natelson BH;Bender AM;Palombini LO;Bittencourt L;Tufik S;Ayappa I;Rapoport DM
睡眠时间因人而异，而且似乎是一种特质。潜在睡眠过程稳定性的差异可能是这种现象的基础。为了研究潜在的机制，我们检查了来自三个独立收集的数据集的基线多导睡眠图（PSG）记录中睡眠持续时间和睡眠连续性之间的关系：1）134例健康对照（年龄37 ± 13岁），他们在睡眠实验室度过了一个晚上，2）阻塞性睡眠呼吸暂停（OSA）患者21例，持续气道正压通气治疗至少2个月（45 ± 12岁，呼吸紊乱指数<15），在睡眠实验室度过一晚，之前有多次PSG研究的经验，和3）62名健康对照（28 ± 6岁），作为较大实验的一部分，他们在睡眠实验室中连续度过2个晚上。对于每个数据集，我们使用总睡眠时间（TST）将受试者分为睡眠时间较短的受试者（S-TST）和睡眠时间较长的受试者（L-TST）。在所有三个数据集中，连续睡眠段的生存曲线显示L-TST比S-TST具有更大的睡眠连续性。相关分析与TST作为一个连续变量证实的结果，控制年龄后的结果也成立。S-TST和L-TST之间的基线清醒表现和嗜睡没有显著差异。总之，在健康对照组和治疗的OSA患者中，睡眠连续性与睡眠持续时间呈正相关。这些发现表明，S-TST可能不同于L-TST的睡眠连续性的过程中，脱落的睡眠持续时间的个体差异的机制的新的光。
Sleep duration varies widely across individuals and appears to be trait-like. Differences in the stability of underlying sleep processes may underlie this phenomenon. To investigate underlying mechanisms, we examined the relationship between sleep duration and sleep continuity in baseline polysomnography (PSG) recordings from three independently collected datasets: 1) 134 healthy controls (ages 37 ± 13 years) from the São Paulo Epidemiologic Sleep Study, who spent one night in a sleep laboratory, 2) 21 obstructive sleep apnea (OSA) patients who were treated with continuous positive airway pressure for at least 2 months (45 ± 12 years, respiratory disturbance index <15), who spent one night in a sleep laboratory with previous experience of multiple PSG studies, and 3) 62 healthy controls (28 ± 6 years) who, as part of larger experiments, spent 2 consecutive nights in a sleep laboratory. For each dataset, we used total sleep time (TST) to separate subjects into those with shorter sleep (S-TST) and those with longer sleep (L-TST). In all three datasets, survival curves of continuous sleep segments showed greater sleep continuity in L-TST than in S-TST. Correlation analyses with TST as a continuous variable corroborated the results; and the results also held true after controlling for age. There were no significant differences in baseline waking performance and sleepiness between S-TST and L-TST. In conclusion, in both healthy controls and treated OSA patients, sleep continuity was positively correlated with sleep duration. These findings suggest that S-TST may differ from L-TST in processes underlying sleep continuity, shedding new light on mechanisms underlying individual differences in sleep duration.