Ras-dependent regulation of c-Jun phosphorylation is mediated by the Ra1 guanine nucleotide exchange factor-Ra1 pathway
Ras-dependent regulation of c-Jun phosphorylation is mediated by the Ra1 guanine nucleotide exchange factor-Ra1 pathway
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DOI：
10.1128/mcb.20.22.8480-8488.2000
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发表时间：
2000-11-01
影响因子：
5.3
通讯作者：
Bos, JL
中科院分区：
文献类型：
--
作者：
De Ruiter, ND;Wolthuis, RMF;Bos, JL
The transcription factor c-jun is critically involved in the regulation of proliferation and differentiation as well as cellular transformation induced by oncogenic Ras. The signal transduction pathways that couple Ras activation to c-Jun phosphorylation are still partially elusive, sere we show that an activated version of the Ras effector Rlf, a guanine nucleotide exchange factor (GEF) of the small GTPase Ral, can induce the phosphorylation of serines 63 and 73 of c-Jun. In addition, we show that growth factor-induced, Ras-mediated phosphorylation of c-Jun is abolished by inhibitory mutants of the RalGEF-Ral pathway. These results suggest that the RalGEF-Ral pathway plays a major role in Ras-dependent c-Jun phosphorylation. Ral-dependent regulation of c-Jun phosphorylation includes JNK, a still elusive JNKK, and possibly Src.
