Vitamin D3-Upregulated protein-1 (VDUP-1) regulates redox-dependent vascular smooth muscle cell proliferation through interaction with thioredoxin
Vitamin D3-Upregulated protein-1 (VDUP-1) regulates redox-dependent vascular smooth muscle cell proliferation through interaction with thioredoxin
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DOI：
10.1161/01.res.0000037982.55074.f6
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发表时间：
2002-10-18
影响因子：
20.1
通讯作者：
Lee, RT
中科院分区：
文献类型：
--
作者：
Schulze, PC;De Keulenaer, GW;Lee, RT
活性氧是重要的细胞信号分子，而硫氧还蛋白（TRX）是细胞氧化还原平衡的关键调节因子。我们研究了TRX与其内源性抑制剂维生素d -3上调蛋白(VDUP)-1在人主动脉平滑肌细胞（SMCs）中的相互作用。腺病毒TRX基因转移使TRX酶活性增强2.7 +/- 0.4倍(P
Reactive oxygen species are important cellular signaling molecules, and thioredoxin (TRX) is a key regulator of cellular redox balance. We investigated the interaction of TRX with its endogenous inhibitor, vitamin D-3-upregulated protein (VDUP)-1, in human aortic smooth muscle cells (SMCs). Adenoviral gene transfer of TRX enhanced TRX enzyme activity 2.7 +/- 0.4-fold (P