Antenatal and Postnatal Growth and 5-Year Cognitive Outcome in Very Preterm Infants
Antenatal and Postnatal Growth and 5-Year Cognitive Outcome in Very Preterm Infants
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DOI：
10.1542/peds.2013-1187
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发表时间：
2014-01-01
期刊：
影响因子：
8
通讯作者：
Rautava, Paivi
中科院分区：
文献类型：
--
作者：
Leppanen, Marika;Lapinleimu, Helena;Rautava, Paivi
目的：研究产前生长如何影响极早产儿的认知结果，并确定出生至5岁之间任何特定时间段的生长与认知结果之间是否存在关联。小于胎龄儿（SGA）和非SGA婴儿分别进行了分析，因为产前生长可能会影响产后growth.METHODS：极低出生体重（1501克）的婴儿出生于2001年和2006年之间，出生于2004年和2006年之间，32孕周谁在图尔库大学医院（n = 181）进行了跟踪。在出生至5岁之间的9个时间点测量婴儿的体重、身长和头围（HC）。生长被确定为测量点之间的z分数变化。在5岁时，使用韦氏学龄前和小学智力量表修订版评估认知发育。生长和全面智商（FSIQ）之间的关联进行了研究。结果：长度和高度的增长与5年的认知结果无关。然而，在非SGA儿童中，出生至2岁校正年龄之间的体重（r = 0.18，P = 0.04）和HC生长（r = 0.25，P = 0.01）与FSIQ相关。在SGA儿童，HC增长（r = 0.33，P = 0.03）在足月年龄与FSIQ.CONCLUSIONS：认知结果是相似的SGA和非SGA非常早产儿。在两个亚组中，生长对认知都有积极影响，但关键时间段是
OBJECTIVES: To study how antenatal growth affects cognitive outcome in very preterm infants and to determine whether there is an association between growth in any particular time period between birth and 5 years of age and cognitive outcome. Small for gestational age (SGA) and non-SGA infants were analyzed separately, because antenatal growth may affect postnatal growth.METHODS: Very low birth weight (, 1501 g) infants born between 2001 and 2006 and infants born at,32 gestational weeks between 2004 and 2006 who were treated at Turku University Hospital (n = 181) were followed. Weight, length, and head circumference (HC) of the infants were measured at 9 time points between birth and 5 years. The growth was determined as a z score change between measurement points. Cognitive development was assessed at 5 years of age with the Wechsler Preschool and Primary Scales of Intelligence-Revised. The association between growth and full-scale IQ (FSIQ) was studied.RESULTS: Growth in length and height was not associated with 5-year cognitive outcome. However, weight (r = 0.18, P = .04) and HC growth (r = 0.25, P = .01) between birth and 2 years of corrected age correlated to FSIQ in non-SGA children. In SGA children, HC growth (r = 0.33, P = .03) around term age correlated to FSIQ.CONCLUSIONS: Cognitive outcome was similar in SGA and non-SGA very preterm infants. Growth affected cognition positively in both subgroups, but the critical time period was