Serum Levels of Glutathione Peroxidase 3 in Overweight and Obese Subjects from Central Mexico
Serum Levels of Glutathione Peroxidase 3 in Overweight and Obese Subjects from Central Mexico
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DOI：
10.1016/j.arcmed.2012.09.001
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发表时间：
2012-10-01
影响因子：
7.7
通讯作者：
Perez-Fuentes, Ricardo
中科院分区：
文献类型：
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作者：
Baez-Duarte, Blanca G.;Zamora-Ginez, Irma;Perez-Fuentes, Ricardo
背景和目的。超重和肥胖被认为是复杂的实体，其中有抗氧化酶浓度的变化。据报道，谷胱甘肽过氧化物酶3 （GPx3）是一种参与氢过氧化物和脂过氧化物还原的细胞外酶，在2型糖尿病（T2D）和肥胖动物模型中显示出基因表达和蛋白质浓度的变化，但GPx3水平在不同人群和不同健康状况下的可变性目前尚不清楚。我们进行了这项研究，以确定来自墨西哥中部的超重和肥胖受试者的GPx3水平。对28名健康受试者（对照组）和133名超重或肥胖受试者（low - ob）的生化特征（血清葡萄糖、胰岛素和血脂）和GPx3浓度进行了测定。低ob组甘油三酯（TAG）浓度高于对照组（201.2 +/- 88.7 vs. 100.3 +/- 46.4 mg/dL, p < 0.05）， TAG/高密度脂蛋白-胆固醇（HDL-C）指数（5.6 +/- 2.8 vs. 2.1 +/- 1.2, p < 0.05）
Background and Aims. Overweight and obesity are considered complex entities in which there are alterations in the concentration of antioxidant enzymes. It has been reported that glutathione peroxidase 3 (GPx3), an extracellular enzyme involved in the reduction of both hydro- and lipoperoxides, shows changes both in gene expression and protein concentration in animal models for type 2 diabetes (T2D) and obesity, but the variability of GPx3 levels in different human populations and under different health conditions are currently unclear. We undertook this study to determine the GPx3 levels in overweight and obese subjects from central Mexico.Methods. Biochemical profile (serum glucose, insulin and lipid profile) and GPx3 concentrations were determined in 28 healthy subjects (control) and 133 subjects who were overweight or obese (OW-OB).Results. The OW-OB group had a higher concentration of triacylglycerides (TAG) compared with the control group (201.2 +/- 88.7 vs. 100.3 +/- 46.4 mg/dL, p < 0.05) and the TAG/high density lipoprotein-cholesterol (HDL-C) index (5.6 +/- 2.8 vs. 2.1 +/- 1.2, p