Distributions of mercury and selenium in rats ingesting mercury selenide nanoparticles
Distributions of mercury and selenium in rats ingesting mercury selenide nanoparticles
复制标题
大鼠摄入硒化汞纳米颗粒体内汞和硒的分布
DOI：
10.1016/j.ecoenv.2021.112867
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发表时间：
2021
影响因子：
6.8
通讯作者：
J.M. Costa Fernandez and Y. Ogra
中科院分区：
文献类型：
--
作者：
K. Takahashi;J. Ruiz Encinar;J.M. Costa Fernandez and Y. Ogra
汞（Hg）是毒性最大的环境污染物之一，通过食物链被生物凝聚。硒（Se）是体内对汞具有拮抗作用的必需元素。汞和硒直接相互作用在器官中形成HgSe纳米粒子（HgSe NPs），从而解释了汞的拮抗特性。推测HgSe NPs的毒性作用低于离子Hg；然而，到目前为止还没有进行精确的评估。在本研究中，我们评估了硒缺乏大鼠摄入的HgSe NPs的分布。在口服HgSe NPs的大鼠中，没有观察到血清硒蛋白从缺乏水平恢复。此外，没有观察到汞和硒通过尿液的排泄。有趣的是，硒蛋白和尿硒代谢物的生物合成需要通过HgSe NPs降解产生硒化物。因此，硒化物和汞似乎不会从体内的HgSe NPs中释放出来。HgSe NPs没有增加器官中汞和硒的浓度，并且几乎所有HgSe NPs都在粪便中被回收，这表明即使在缺硒大鼠中HgSe NPs也没有或低生物可及性。这些结果表明，HgSe NPs具有生物惰性，不会成为汞的二次环境污染物。
Mercury (Hg) is one of the most toxic environmental pollutants, and is biocondensed via the food chain. Selenium (Se) is an essential element that possesses an antagonistic property towards Hg in vivo. The antagonistic property is explained by the assumption that Hg and Se directly interact to form HgSe nanoparticles (HgSe NPs) in organs. It is presumed that the toxic effects of HgSe NPs are lower than that of ionic Hg; however, no precise evaluation has been conducted so far. In the present study, we evaluated the distribution of HgSe NPs ingested in Se-deficient rats. The recovery of serum selenoproteins from a deficient level was not observed in rats orally administered HgSe NPs. In addition, the excretion of Hg and Se via urine was not observed. Interestingly, the biosynthesis of selenoproteins and urinary selenometabolites would have required the production of selenide through the degradation of HgSe NPs. Therefore, it seems that selenide and Hg are not released from HgSe NPs in vivo. The administration of HgSe NPs did not increase Hg and Se concentrations in organs, and almost all HgSe NPs were recovered in feces, indicating no or low bioaccessibility of HgSe NPs even in Se-deficient rats. These results suggest that HgSe NPs are biologically inert and do not become a secondary environmental pollutant of Hg.