Soy and the exercise-induced inflammatory response in postmenopausal women
Soy and the exercise-induced inflammatory response in postmenopausal women
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DOI：
10.1139/h10-015
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发表时间：
2010-06-01
影响因子：
3.4
通讯作者：
Willoughby, Darryn S.
中科院分区：
文献类型：
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作者：
Beavers, Kristen M.;Serra, Monica C.;Willoughby, Darryn S.
衰老与体内炎症和氧化应激的增加有关，这两者都会对健康产生负面影响。通过饮食对策成功减弱此类过程具有重大的公共卫生影响。大豆食品作为优质蛋白质和异黄酮的来源，可能会改善这些指数，尽管对健康绝经后妇女的影响尚不清楚。对 31 名绝经后妇女进行了一项单盲、随机对照试验，她们被分配每天饮用 3 份大豆 (n = 16) 或牛奶 (n = 15)，持续 4 周。在补充后、进行离心运动以引发炎症反应之前和之后，测量全身炎症参数（肿瘤坏死因子-α (TNF-α)、白细胞介素 1 β (IL-1 β) 和白细胞介素 6 (IL-6)）和氧化防御系统（超氧化物歧化酶 (SOD)、谷胱甘肽过氧化物酶、环氧合酶-2）。观察到血浆 TNF-α 存在显着的按时间组别效应（p = 0.02），乳制品组的数值在补充后增加，然后在运动后阶段下降。此外，在运动后观察到血浆 SOD (p < 0.0001) 和 IL-6 (p < 0.0001) 存在显着的时间效应。我们研究的总体结果并不支持这样的观点：每天摄入豆奶 4 周可以减弱炎症或氧化防御标志物的全身升高。然而，数据确实表明，本研究中使用的下坡跑方案可以有效改变炎症和氧化防御酶活性的全身标志物，并且摄入大豆可能有助于防止血浆 TNF-α 的波动。
Aging is associated with increasing inflammation and oxidative stress in the body, both of which can have negative health effects. Successful attenuation of such processes with dietary countermeasures has major public health implications. Soy foods, as a source of high-quality protein and isoflavones, may improve such indices, although the effects in healthy postmenopausal women are not well delineated. A single-blind, randomized controlled trial was conducted in 31 postmenopausal women who were assigned to consume 3 servings of soy (n = 16) or dairy (n = 15) milk per day for 4 weeks. Parameters of systemic inflammation (tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), and interleukin-6 (IL-6)) and the oxidative defense system (superoxide dismutase (SOD), glutathione peroxidase, cyclooxygenase-2) were measured post supplementation, before and after an eccentric exercise bout performed to elicit an inflammatory response. A significant group-by-time effect for plasma TNF-alpha was observed (p = 0.02), with values in the dairy group increased post supplementation and then decreasing into the postexercise period. Additionally, significant time effects were observed for plasma SOD (p < 0.0001) and IL-6 (p < 0.0001) in the postexercise period. Overall results from our study do not support the notion that 4 weeks of daily soy milk ingestion can attenuate systemic elevations in markers of inflammation or oxidative defense. However, data do suggest that the downhill-running protocol utilized in this study can be effective in altering systemic markers of inflammation and oxidative defense enzyme activity, and that the ingestion of soy may help prevent fluctuations in plasma TNF-alpha.