IL-6 Promotes T Cell Proliferation and Expansion under Inflammatory Conditions in Association with Low-Level RORγt Expression.
IL-6 Promotes T Cell Proliferation and Expansion under Inflammatory Conditions in Association with Low-Level RORγt Expression.
复制标题
DOI：
10.4049/jimmunol.1800016
复制
发表时间：
2018-11-15
期刊：
影响因子：
--
通讯作者：
Geiger TL
中科院分区：
文献类型：
--
作者：
Li B;Jones LL;Geiger TL
IL-6是急性和慢性炎症的关键驱动力，已被报道作为T细胞生存因子。IL-6对T细胞稳态的影响尚未得到很好的解决。我们证明，IL-6信号在炎症条件下驱动T细胞的扩张，而不是在正常的稳态条件下。在炎症过程中，IL-6Rα缺陷的T细胞无法有效地与野生型T细胞竞争。IL-6促进T细胞增殖，这与rORγt转录因子低水平表达有关。与Th17细胞相比，T细胞上调RORC mRNA的水平显著降低。通过基因敲除或小分子抑制剂阻断RoRγt可导致与IL-6Rα缺陷T细胞类似的T细胞扩增缺陷。我们的结果表明，IL-6在炎症过程中T细胞的扩增中起关键作用，并可能与低水平的RoR-γ-t的瞬时诱导有关。
IL-6 is a critical driver of acute and chronic inflammation, and has been reported to act as a T cell survival factor. The influence of IL-6 on T cell homeostasis is not well resolved. We demonstrate that IL-6 signaling drives T cell expansion under inflammatory conditions, but not during normal homeostasis. During inflammation, IL-6Rα-deficient T cells are unable to effectively compete with wild type T cells. IL-6 promotes T cell proliferation, and this is associated with low-level expression of the RORγt transcription factor. T cells upregulate Rorc mRNA at levels substantially diminished from that seen in Th17 cells. Blockade of RORγt through genetic knock-out or a small molecule inhibitor leads to T cell expansion defects comparable to those in IL-6Rα-deficient T cells. Our results indicate that IL-6 plays a key role in T cell expansion during inflammation, and implicates a role for the transient induction of low-level RORγt.
登录
查看更多内容
影响因子：
64.5
作者：
Ivanov, Ivaylo I.;McKenzie, Brent S.;Littman, Dan R.
通讯作者：
Littman, Dan R.
影响因子：
64.8
作者：
Bettelli, E;Carrier, YJ;Kuchroo, VK
通讯作者：
Kuchroo, VK
DNA-PKcs 在响应 DNA 损伤和细胞周期进展的 H2AX 磷酸化调节中起主导作用。
影响因子：
--
作者：
An J;Huang YC;Xu QZ;Zhou LJ;Shang ZF;Huang B;Wang Y;Liu XD;Wu DC;Zhou PK
通讯作者：
Zhou PK
DOI：
10.4049/jimmunol.1402953
发表时间：
2016-04-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Jones LL;Alli R;Li B;Geiger TL
通讯作者：
Geiger TL
影响因子：
4.8
作者：
Lacroix, Marine;Rousseau, Francois;Ferlin, Walter
通讯作者：
Ferlin, Walter