Endocrine levels at the start of treatment are associated with subsequent psychological adjustment in cancer patients with metastatic disease
Endocrine levels at the start of treatment are associated with subsequent psychological adjustment in cancer patients with metastatic disease
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DOI：
10.1097/00006842-200111000-00014
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发表时间：
2001-11-01
影响因子：
3.3
通讯作者：
Amato, RJ
中科院分区：
文献类型：
--
作者：
Cohen, L;de Moor, C;Amato, RJ
目的：本研究探讨了癌症治疗开始时的激素水平与随后的心理疾病之间的关系。研究方法：27例转移性肾细胞癌患者和18例转移性黑色素瘤患者在治疗过程中完成了3次评估：治疗开始时（基线）、治疗结束时（基线后3周）和1个月后的随访。皮质醇、去甲肾上腺素和肾上腺素水平在基线时使用15小时尿样测量。在每次评估时，患者完成事件影响量表（IES）和简明症状量表（BSI）。结果：通过IES和BSI测量，患者在整个治疗过程中报告了中度痛苦。治疗开始时的去甲肾上腺素水平与治疗结束时和随访时的IES总评分呈正相关，皮质醇水平与基线IES和总体痛苦评分校正后随访时的IES总评分呈正相关。去甲肾上腺素水平也与随访时的抑郁评分呈正相关，皮质醇水平与治疗结束时的抑郁评分呈正相关，并在调整基线抑郁和总体痛苦评分后进行随访。结论：癌症治疗开始时的激素水平与随后的心理调整有关。
Objective: This study examined the association between hormonal profiles at the start of cancer treatment and subsequent psychological symptomatology. Methods: Twenty-seven patients with metastatic renal cell carcinoma and 18 patients with metastatic melanoma completed three assessments during the course of treatment: at the start of treatment (baseline), at the end of treatment (3 weeks after baseline), and at a follow-up appointment 1 month later. Cortisol, norepinephrine, and epinephrine levels were measured at baseline using 15-hour urine samples. At each assessment, patients completed the Impact of Event Scale (IES) and the Brief Symptom Inventory (BSI). Results: Patients reported moderate levels of distress throughout treatment as measured by the IES and BSI. Norepinephrine levels at the start of treatment were positively associated with IES total scores at the end of treatment and at follow-Lip, and cortisol levels were positively associated with IES total scores at follow-up after adjusting for baseline IES and overall distress scores. Norepinephrine levels were also positively associated with depression scores at follow-up, and cortisol levels were positively associated with depression scores at the end of treatment and at follow-up after adjusting for baseline depression and overall distress scores. Conclusions: Hormonal profiles at the start of cancer treatment are associated with subsequent psychological adjustment.