Homeostatic expansion occurs independently costimulatory signals
Homeostatic expansion occurs independently costimulatory signals
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DOI：
10.4049/jimmunol.167.10.5664
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发表时间：
2001-11-15
影响因子：
4.4
通讯作者：
Jameson, SC
中科院分区：
文献类型：
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作者：
Prlic, M;Blazar, BR;Jameson, SC
在淋巴细胞减少的小鼠中，幼稚T细胞经历稳态增殖，这一过程涉及TCR对特定自身肽/MHC复合物的识别。由于共刺激信号调节T细胞对外来Ags的反应，我们想知道它们是否也调节稳态扩张。我们在这项研究中报道，CD4和CD8 T细胞的稳态扩张独立于共刺激信号发生。通过CD28/B7、CD40L/CD40或4-1BB/4-1BBL相互作用介导。使用DO11.10 TCR转基因T细胞，我们证实了CD28的表达对于稳态扩增是必不可少的，并且表明内源性CD4(+)CD25（+）调节细胞的存在对稳态扩增没有明显影响。这些发现对T细胞稳态和自身免疫调节的意义进行了讨论。
Naive T cells undergo homeostatic proliferation in lymphopenic mice, a process that involves TCR recognition of specific self peptide/MHC complexes. Since costimulation signals regulate the T cell response to foreign Ags, we asked whether they also regulate homeostatic expansion. We report in this study that homeostatic expansion of CD4 and CD8 T cells occurs independently of costimulation signals. mediated through CD28/B7, CD40L/CD40, or 4-1BB/4-1BBL interactions. Using DO11.10 TCR transgenic T cells, we confirmed that CD28 expression was dispensable for homeostatic expansion, and showed that the presence of endogenous CD4(+)CD25(+) regulatory cells did not detectably influence homeostatic expansion. The implications of these findings with respect to regulation of T cell homeostasis and autoimmunity are discussed.