Platelet-derived growth factor receptor α in hepatocellular carcinoma is a prognostic marker independent of underlying liver cirrhosis.
Platelet-derived growth factor receptor α in hepatocellular carcinoma is a prognostic marker independent of underlying liver cirrhosis.
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DOI：
10.18632/oncotarget.17134
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发表时间：
2017-06-13
期刊：
影响因子：
--
通讯作者：
Lee JI
中科院分区：
文献类型：
--
作者：
Yu JH;Kim JM;Kim JK;Choi SJ;Lee KS;Lee JW;Chang HY;Lee JI
血小板源性生长因子受体α（PDGFRα）被认为是肝细胞癌（HCC）的预后标志物。由于PDGFRα也被认为是活化的肝星状细胞（HSC）的标志物，因此本研究旨在研究HCC中PDGFRα的表达是否依赖于背景肝纤维化状况。肿瘤病灶中PDGFRα的强表达与肝癌根治性切除术后生存率降低相关。肿瘤中PDGFRα的表达与胶原α1（I）、卵磷脂视黄醇酰基转移酶和平滑肌α-肌动蛋白的增加相关，表明肿瘤部位的HSC增加。肿瘤部位的PDGFRα表达与基础肝纤维化/肝硬化无关，也与邻近非肿瘤部位的PDGFRα表达无关。接受肝切除作为治愈性治疗的HCC患者纳入本研究。采用95例肝组织标本，构建组织芯片，免疫组化法检测肿瘤和非肿瘤部位PDGFRα的表达。比较肿瘤和匹配的非肿瘤部位的PDGFRα表达。对16例HCC患者新鲜冰冻肝组织进行PDGFRα和纤维化相关基因的基因表达分析。我们的研究结果表明，PDGFRα在HCC中的过表达是一个预后标志物，与邻近非肿瘤部位的肝纤维化状态无关。
Platelet-derived growth factor receptor alpha (PDGFRα) is suggested as a prognosis marker for hepatocellular carcinoma (HCC). Since PDGFRα is also known as a marker for activated hepatic stellate cells (HSCs), this study aimed to investigate whether PDGFRα expression in HCC was dependent on the background liver fibrous condition. Strong PDGFRα expression in the tumor lesions was associated with decreased survival after curative HCC resection. Expression of PDGFRα in the tumor correlated with increased collagen α1(I), lecithin retinol acyltransferase, and smooth muscle α-actin suggesting increased HSCs in tumor sites. The expression of PDGFRα in the tumor sites was associated neither with underlying liver fibrosis/cirrhosis nor with the expression of PDGFRα in adjacent non-tumor sites of the liver. Patients with HCC who underwent liver resection as curative treatment were included in this study. Using liver samples of 95 patients, tissue microarray was constructed and immunohistochemical study of PDGFRα was conducted in both tumor and non-tumor sites. PDGFRα expression in tumor and matching non-tumor sites was compared. Freshly frozen liver tissue specimens of 16 HCC patients were used for gene expression analysis of PDGFRα and fibrosis related genes. Our results suggest that PDGFRα overexpression in HCC is a prognostic marker independent of adjacent non-tumor site liver fibrosis status.
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影响因子：
3.7
作者：
Hayes BJ;Riehle KJ;Shimizu-Albergine M;Bauer RL;Hudkins KL;Johansson F;Yeh MM;Mahoney WM Jr;Yeung RS;Campbell JS
通讯作者：
Campbell JS
DOI：
10.1073/pnas.0409722102
发表时间：
2005-03-01
影响因子：
11.1
作者：
Campbell, JS;Hughes, SD;Fausto, N
通讯作者：
Fausto, N
DOI：
10.1056/nejmoa0804525
发表时间：
2008-11-06
期刊：
The New England journal of medicine
影响因子：
--
作者：
Hoshida Y;Villanueva A;Kobayashi M;Peix J;Chiang DY;Camargo A;Gupta S;Moore J;Wrobel MJ;Lerner J;Reich M;Chan JA;Glickman JN;Ikeda K;Hashimoto M;Watanabe G;Daidone MG;Roayaie S;Schwartz M;Thung S;Salvesen HB;Gabriel S;Mazzaferro V;Bruix J;Friedman SL;Kumada H;Llovet JM;Golub TR
通讯作者：
Golub TR
影响因子：
25.7
作者：
Lee, Jung Il;Campbel, Jean S.
通讯作者：
Campbel, Jean S.
影响因子：
3.5
作者：
Thieringer, Florian;Maass, Thorsten;Kanzler, Stephan
通讯作者：
Kanzler, Stephan