Application of new international classification of adult-onset diabetes in Chinese inpatients with diabetes mellitus
Application of new international classification of adult-onset diabetes in Chinese inpatients with diabetes mellitus
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新的成人发病糖尿病国际分类在中国住院糖尿病患者中的应用
DOI：
10.1002/dmrr.3427
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发表时间：
2020-12-12
影响因子：
8
通讯作者：
Guo, Lixin
中科院分区：
文献类型：
--
作者：
Wang, Weihao;Pei, Xiaobei;Guo, Lixin
背景：确定新的国际分类方法是否适用于我国住院糖尿病患者。方法选择2017年1月至2018年12月在三级护理中心住院的成人糖尿病患者。K-均值聚类分析是基于谷氨酸脱羧酶抗体、体重指数、糖化血红蛋白、稳态模型评估的β细胞功能、胰岛素抵抗指数和糖尿病确诊时的年龄进行的。用卡方检验分析糖尿病相关并发症和糖尿病家族史的亚组间差异。P共有1152名住院的糖尿病患者纳入研究。通过聚类分析得到5个亚组，其中轻度肥胖相关DM亚组人群比例最高(34.55%)，其次是轻度年龄相关性DM(21.55%)、重度胰岛素缺乏DM(20.51%)、重度胰岛素抵抗DM(19.02%)和重度自身免疫性DM亚组(4.36%)。糖尿病视网膜病变、糖尿病周围血管病变、糖尿病酮症、冠心病、高血压、糖尿病家族史在各亚组间差异有统计学意义(均P<；0.05)。结论该分类方法适用于中国地区住院的成年DM患者。这可能有助于为糖尿病患者制定策略，从而改善这些患者的糖尿病管理。
Background To determine whether the new international cluster-based classification method can be applied to Chinese inpatients with diabetes mellitus (DM).Methods Adult patients with DM hospitalized in our tertiary care centre from January 2017 to December 2018 were included in the study. K-means cluster analysis was done in clusters based on glutamic acid decarboxylase antibodies, body mass index, glycosylated haemoglobin, homeostasis model-assessed beta cell function, insulin resistance index, and age at diagnosis of DM. Chi-square test was used to analyse inter-subgroup differences in DM-related complications and family history of DM. p A total of 1152 inpatients with DM were included in the study. Five subgroups were obtained by cluster analysis with highest proportion of population in mild obesity-related DM subgroup (34.55%), followed by mild age-related DM (21.55%), severe insulin deficiency DM (20.51%), severe insulin resistance DM (19.02%), and severe autoimmune DM subgroup (4.36%). The prevalence of diabetic retinopathy, diabetic peripheral vascular disease, diabetic ketosis, coronary heart disease, hypertension, and family history of DM differed significantly among the subgroups (p < 0.05 for all).Conclusions This cluster-based classification could be applied to hospitalized adult patients with DM in China. It might help in strategizing for DM patients, and hence, improve management of DM in these patients.