Atherosclerotic plaque burden of middle cerebral artery and extracranial carotid artery characterized by MRI in patients with acute ischemic stroke in China: association and clinical relevance
Atherosclerotic plaque burden of middle cerebral artery and extracranial carotid artery characterized by MRI in patients with acute ischemic stroke in China: association and clinical relevance
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中国急性缺血性脑卒中患者大脑中动脉和颅外颈动脉粥样硬化斑块负荷的 MRI 特征：关联性和临床相关性。
DOI：
10.1080/01616412.2017.1281196
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发表时间：
2017-01-01
影响因子：
1.9
通讯作者：
Liu, Xiaosheng
中科院分区：
文献类型：
--
作者：
Cao, Ye;Sun, Yi;Liu, Xiaosheng
目的：本研究旨在比较动脉粥样硬化斑块负荷大脑中动脉（MCA）和颅外颈动脉（ECA）在缺血性中风患者使用高分辨率，黑血（HR BB）MRI，并探讨斑块负荷之间的关系，发现在两个动脉和中风severity.Methods：最近缺血性中风的所有受试者进行MCA和ECA HR BB MRI在3.0特斯拉。记录每段动脉斑块的厚度、面积和信号强度。通过标准化管壁指数（NWI=管壁面积/总血管面积× 100%）计算斑块负荷。所有患者在入院时均接受美国国立卫生研究院卒中量表（NIHSS）评分测量的临床卒中严重程度评分。MCA的NWI显著大于同侧ECA（症状性MCA与ECA：58.048.19与37.53 +/- 10.25，p
Objectives: This study sought to compare the atherosclerotic plaque burden between middle cerebral artery (MCA) and extracranial carotid artery (ECA) in ischemic stroke patients using high-resolution, black-blood (HR BB) MRI and to investigate the relationship between plaque burden found in both arteries and stroke severity.Methods: All subjects with recent ischemic stroke underwent MCA and ECA HR BB MRI at 3.0 Tesla. For each artery segment, the thickness, area and signal intensities of plaques were recorded. Plaque burden, as measured by normalized wall index (NWI=wall area/total vessel areax100%) were calculated. All patients received a clinical stroke severity score as measured by the National Institutes of Health Stroke Scale (NIHSS) scores at the time of admission.Results: A total of 65 stroke subjects were included in the final analysis. MCA exhibited significantly greater NWI than the ipsilateral ECA (symptomatic MCA vs. ECA: 58.048.19 vs. 37.53 +/- 10.25, p