Is the decreased high-density lipoprotein cholesterol in the metabolic syndrome due to cellular lipid efflux defect?
Is the decreased high-density lipoprotein cholesterol in the metabolic syndrome due to cellular lipid efflux defect?
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DOI：
10.1210/jc.2003-031213
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发表时间：
2004-02-01
影响因子：
5.8
通讯作者：
Genest, J
中科院分区：
文献类型：
--
作者：
Alenezi, MY;Marcil, M;Genest, J
代谢综合征（MS）与心血管疾病有关。 MS 中观察到的低高密度脂蛋白胆固醇 (HDL-C) 与含载脂蛋白 B 的脂蛋白的肝脏分泌增加有关。由于 ABCA1 基因缺陷（丹吉尔病）而导致 HDL-C 低和细胞脂质流出异常的患者血浆甘油三酯也升高。在本研究中，我们检查了低 HDL-C 患者的细胞胆固醇和磷脂流出以及 MS 的特征。选择了 44 名 HDL-C 低于年龄和性别第五百分位的患者。 MS 的定义是低 HDL-C 和至少两个附加特征：体重指数至少 30 kg/m(2)、血浆甘油三酯至少 150 mg/dl、空腹血糖至少 110 mg/dl 以及血压至少 130/85 mm Hg。对从研究对象、九名正常对照者和六名患有丹吉尔病的对象获得的成纤维细胞进行细胞脂质流出检测。在 22 名确诊为 MS 的患者中，HDL-C 为 21 +/- 7 mg/dl，甘油三酯水平为 340 +/- 157 mg/dl，细胞胆固醇和磷脂流出量分别为对照的 107 +/- 18% 和 105 +/- 17%。没有 MS 和低 HDL-C 患者表现出细胞脂质流出缺陷。我们的结论是，原代细胞脂质流出缺陷不会导致 MS 中经常遇到的低 HDL-C。
The metabolic syndrome (MS) is associated with cardiovascular disease. The low high-density lipoprotein cholesterol (HDL-C) seen in the MS is associated with increased hepatic secretion of apolipoprotein B-containing lipoproteins. Patients with low HDL-C and abnormal cellular lipid efflux due to ABCA1 gene defects (Tangier disease) also have elevated plasma triglycerides. In the present study, we examined the cellular cholesterol and phospholipid efflux in patients with low HDL-C and features of the MS. Forty-four patients with a HDL-C below the fifth percentile for age and gender were selected. The MS was defined by a low HDL-C and at least two additional features: body mass index at least 30 kg/m(2), plasma triglycerides at least 150 mg/dl, fasting glucose at least 110 mg/dl, and blood pressure at least 130/85 mm Hg. Cellular lipid efflux was examined on fibroblasts obtained from study subjects, nine normal controls and six subjects with Tangier disease. In 22 patients identified with the MS, HDL-C was 21 +/- 7 mg/dl, triglyceride levels were 340 +/- 157 mg/dl, and cellular cholesterol and phospholipid efflux were 107 +/- 18% and 105 +/- 17% of controls, respectively. No patient with the MS and low HDL-C showed a cellular lipid efflux defect. We conclude that primary cellular lipid efflux defects do not contribute to the low HDL-C frequently encountered in the MS.