Near-instant noninvasive optical imaging of tissue perfusion for vascular assessment
Near-instant noninvasive optical imaging of tissue perfusion for vascular assessment
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DOI：
10.1016/j.jvs.2018.06.202
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发表时间：
2019-02-01
影响因子：
4.3
通讯作者：
Armstrong, David G.
中科院分区：
文献类型：
--
作者：
Weinkauf, Craig;Mazhar, Amaan;Armstrong, David G.
背景资料：非侵入性血管检查对于识别可能从手术血运重建中受益的患者至关重要，但目前的检查在糖尿病患者中具有明显的局限性。本研究旨在评价空间频域成像（SFDI）评估下肢血供的能力，SFDI是一种能够测量组织氧饱和度（StO（2））和组织血红蛋白的光学成像方法。踝臂指数，趾臂指数，踏板多普勒波形，在47例有或无糖尿病的患者中前瞻性评价了SFDI图像，这些患者中存在外周动脉疾病（PAD）的担忧。SFDI是一种非接触式光学成像技术，它使用结构化照明来量化地下（2- 3 mm深度）在大视野内真皮微循环（HbT（1））和大循环（HbT（2））中的StO（2）和组织血红蛋白（15 x 20 cm）。结果：这证明了SFDI能够捕获足部足底方面灌注的可靠临床测量结果。SFDI StO（2）值可区分有无动脉疾病的非糖尿病患者，定义为踝臂指数< 0.9（P = 0.06），但仅限于糖尿病患者（P = 0.43）。与非糖尿病患者相比，糖尿病患者的StO（2）升高，HbT（1）降低（P
Background: Noninvasive vascular tests are critical for identifying patients who may benefit from surgical revascularization, but current tests have significant limitations in people with diabetes. This study aimed to evaluate the ability of spatial frequency domain imaging (SFDI), an optical imaging method capable of measuring tissue oxygen saturation (StO(2)) and tissue hemoglobin, to assess lower extremity blood supply.Methods: Ankle-brachial index, toe-brachial index, pedal Doppler waveforms, and SFDI images were prospectively evaluated in 47 consecutive patients with and without diabetes in whom there was concern for peripheral artery disease (PAD). SFDI is a noncontact optical imaging technology that uses structured illumination to quantify subsurface (2-3mm in depth) StO(2) and tissue hemoglobin in the dermal microcirculation (HbT(1)) and macrocirculation (HbT(2)) over a large field of view (15 x 20 cm) within 10 seconds.Results: This demonstrates the ability of SFDI to capture reliable clinical measurements of perfusion in plantar aspects of the feet. SFDI StO(2) values differentiate nondiabetic patients with and without arterial disease, defined as ankle-brachial index < 0.9 (P =.06), but are limited in those with diabetes (P =.43). An elevated StO(2) and reduced HbT(1) are observed in people with diabetes compared with nondiabetic patients (P