A Novel Instantaneous Self-Assembled Hollow MOF-Derived Nanodrug for Microwave Thermo-Chemotherapy in Triple-Negative Breast Cancer.
A Novel Instantaneous Self-Assembled Hollow MOF-Derived Nanodrug for Microwave Thermo-Chemotherapy in Triple-Negative Breast Cancer.
复制标题
DOI：
10.1021/acsami.2c13561
复制
发表时间：
2022-11
影响因子：
9.5
通讯作者：
Qiong Wu;Ting Li;Jingjing Song;Xiaohan Sun;X. Ren;Changhui Fu;Lufeng Chen;Longfei Tan;
中科院分区：
文献类型：
--
作者：
Qiong Wu;Ting Li;Jingjing Song;Xiaohan Sun;X. Ren;Changhui Fu;Lufeng Chen;Longfei Tan;
金属有机骨架中空材料因其独特的性能在生物医学领域得到了广泛的应用，并提出了不同的合成方法。然而，到目前为止，中空MOFs的大规模使用大多受到合成方法的时效性的限制。在此，我们提出了一种新的超声气溶胶流动策略，用于在一个步骤中瞬时合成Zr-MOF衍生的空心球复合物（ZC-HSC）。通过快速瞬时加热，金属盐和有机配体之间的配位沿着溶剂的迅速蒸发而发生。整个过程仅持续约21秒，相比之下，传统合成方法需要几个小时甚至几天的步骤。基于ZC-HSC，我们设计了一种具有操纵肿瘤微环境功能的纳米药物，通过改善肿瘤缺氧和炎症微环境，促进抗血管生成治疗，重塑肿瘤微环境。纳米药物联合微波热化疗，有效治疗三阴性乳腺癌（肿瘤细胞在常氧和低氧状态下存活率分别仅为34.76%和31.05%，动物水平抑瘤率达到87.9%），为治疗三阴性乳腺癌提供了新的理论依据。这种快速、一步、连续的超声气溶胶流动策略在MOF衍生中空材料的合成中具有光明的前景，并促进生物纳米材料大规模应用的进一步发展。
Hollow materials derived from metal-organic frameworks (MOFs) have emerged in the biomedical field due to their unique properties, and different synthesis methods have been proposed. However, so far, the large-scale use of hollow MOFs is mostly limited by the timeliness of synthesis methods. Herein, we propose a new ultrasonic aerosol flow strategy for the instantaneous synthesis of a Zr-MOF-derived hollow sphere complex (ZC-HSC) in only one step. Through rapid transient heating, the coordination between metal salts and organic ligands occurs along with prompt evaporation of the solvent. The whole process lasts for only about 21 s, compared with several steps that take hours or even days for conventional synthesis methods. Based on the ZC-HSC, we designed a nanodrug with the functions of manipulating the tumor microenvironment, which can reshape the tumor microenvironment by improving tumor hypoxia and inflammatory microenvironment and promoting antiangiogenic therapy. Combined with microwave thermo-chemotherapy, the nanodrugs effectively treat triple-negative breast cancer (the tumor cell survival rate was only 34.76 and 31.05% in normoxic and hypoxic states, respectively, and the tumor inhibition rate reached 87.9% at the animal level), providing a new theoretical basis for the treatment of triple-negative breast cancer. This rapid, one-step, and continuous ultrasonic aerosol flow strategy has bright prospects in the synthesis of MOF-derived hollow materials and promotes the further development of large-scale applications of biological nanomaterials.