A simple method for NMR t(1) noise suppression.
A simple method for NMR t(1) noise suppression.
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DOI：
10.1016/j.jmr.2016.12.014
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发表时间：
2017-03
期刊：
影响因子：
--
通讯作者：
Post CB
中科院分区：
文献类型：
--
作者：
Mo H;Harwood JS;Yang D;Post CB
t1 噪声表现为沿着 2D 或 nD NMR 谱的间接 t1 (F1) 维度的随机或半随机杂散条纹。它会显着降低频谱质量，特别是对于具有强对角线信号（例如 NOESY）的频谱，因为有用和弱的交叉峰很容易被 t1 噪声掩盖。 t1 噪声的重要影响因素之一是 t1 采集期间不需要的半随机 F2 信号调制。因此，来自不同采集的 t1 噪声不太可能彼此强烈相关。就 NOESY 而言，与具有相同总采集时间和分辨率的传统采集相比，多个光谱的共同相加显着降低了 t1 噪声。
t1 noise appears as random or semi-random spurious streaks along the indirect t1 (F1) dimension of a 2D or nD NMR spectrum. It can significantly downgrade spectral quality, especially for spectra with strong diagonal signals such as NOESY, because useful and weak cross-peaks can be easily buried under t1 noise. One of the significant contributing factors to t1 noise is unwanted and semi-random F2 signal modulation during t1 acquisition. As such, t1 noise from different acquisitions is unlikely to correlate with each other strongly. In the case of NOESY, co-addition of multiple spectra significantly reduces t1 noise compared with conventional acquisition with the same amount of total acquisition time and resolution.