Progressive supranuclear palsy with dementia: Cortical pathology
Progressive supranuclear palsy with dementia: Cortical pathology
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DOI：
10.1097/00005072-199904000-00006
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发表时间：
1999-04-01
影响因子：
3.2
通讯作者：
White, CL
中科院分区：
文献类型：
--
作者：
Bigio, EH;Brown, DF;White, CL
进行性核上性麻痹（PSP）患者经常发展为痴呆，并且PSP的皮质病理学已被记录。然而，目前还没有相关的报告与皮质病理的PSP痴呆。我们假设，PSP的认知功能障碍的情况下，将有更严重的皮质tau病变比那些没有。我们比较了7例有认知功能障碍的PSP（第1组）和4例无认知功能障碍的PSP（第2组）。两组的皮质下tau病理学几乎相同。第1组的皮质tau病理学显著不同，平均为中度，而第2组为最小。皮质神经胶质tau蛋白在PSP痴呆病例中的积累表明，神经病理学是PSP痴呆病因的核心。
Patients with progressive supranuclear palsy (PSP) often develop dementia, and cortical pathology has been documented in PSP. However, there are no reports correlating dementia in PSP with cortical pathology. We hypothesized that cases of PSP presenting with cognitive impairment would have more severe cortical tau pathology than those without. We compared 7 cases of PSP presenting with cognitive deficits (group 1) with 4 cases of PSP that did not (group 2). The subcortical tau pathology was almost identical in both groups. The cortical tau pathology was strikingly different in group 1, in which it was on average moderate, compared with group 2, in which it was minimal. The accumulation of cortical neuronoglial tau in PSP cases with dementia suggests that neurofibrillary pathology is central to the cause of dementia in PSP.