SOX4 expression levels in urothelial bladder carcinoma
SOX4 expression levels in urothelial bladder carcinoma
复制标题
DOI：
10.1016/j.prp.2011.05.005
复制
发表时间：
2011-01-01
影响因子：
2.8
通讯作者：
Bagci, Hasan
中科院分区：
文献类型：
--
作者：
Gunes, Sezgin;Yegin, Zeynep;Bagci, Hasan
在多种人类癌症中已经报道了高水平的SOX 4基因表达。该蛋白可能在细胞凋亡途径中起作用，导致细胞死亡以及肿瘤发生。本研究的目的是研究SOX 4在膀胱癌中的表达水平。膀胱肿瘤样本来自57例膀胱癌和13例正常膀胱活检组织。采用免疫组化和实时荧光定量PCR检测膀胱癌中SOX 4的表达水平。SOX4基因在膀胱肿瘤中的表达是正常组织的2.2倍。通过免疫染色证实蛋白质的存在。膀胱肿瘤组织与正常膀胱组织的免疫组化染色差异有显著性意义（P=0.001）。提示SOX 4基因可能在膀胱癌的发生发展中起一定作用。(C)2011年Elsevier GmbH。All rights reserved.
High levels of SOX4 gene expression have been reported in a variety of human cancers. The protein may function in the apoptosis pathway, leading to cell death as well as to tumorigenesis. The aim of this study was to investigate the levels of SOX4 expression in bladder cancer. Urinary bladder tumor samples were obtained from 57 bladder cancer and 13 normal bladder biopsies. The levels of SOX4 expression in bladder cancer were determined by immunohistochemistry and real-time PCR. SOX4 gene expression was increased 2.2 times in bladder tumors as compared with normal tissue. The presence of protein was confirmed by immunostaining. There were significant differences between immunostaining of bladder tumors and normal bladder tissue (P=0.001). The present data suggest that SOX4 gene may have a role in bladder cancer tumorigenesis. (C) 2011 Elsevier GmbH. All rights reserved.