Individual Differences in Anterior Cingulate Activation Associated with Attentional Bias Predict Cocaine Use After Treatment
Individual Differences in Anterior Cingulate Activation Associated with Attentional Bias Predict Cocaine Use After Treatment
复制标题
DOI：
10.1038/npp.2013.7
复制
发表时间：
2013-05-01
影响因子：
7.6
通讯作者：
Franken, Ingmar H. A.
中科院分区：
文献类型：
--
作者：
Marhe, Reshmi;Luijten, Maartje;Franken, Ingmar H. A.
药物依赖患者往往在治疗后重新吸毒。行为研究表明，对药物线索的注意偏向增强是复吸的前兆。目前的功能性磁共振成像（fMRI）研究检查是否大脑区域参与注意力偏差是预测可卡因治疗后的使用。注意力偏差相关的大脑活动进行了测量可卡因Stroop任务可卡因依赖患者在他们的第一个星期的戒毒治疗，并用于预测可卡因的使用在3个月的随访。除了其他措施，如自我报告的物质严重性，渴望和行为注意力偏差的预测价值的注意力偏差相关的大脑活动在先验定义的感兴趣的区域进行了检查。结果表明，治疗前一周的渴望和背侧前扣带皮层（dACC）中注意力偏差相关活动的个体差异是3个月随访时可卡因使用天数的显著预测因素，解释方差为45%。dACC中的大脑活动独特地为预测模型贡献了22%的解释方差。这些发现表明，dACC中与过度活跃的注意力偏差相关的大脑活动可能早在戒毒治疗的第一周就成为复发脆弱性的生物标志物。最终，这可能有助于制定个性化的治疗干预措施，以降低复发风险。Neuropsychopharmacology（2013）38，1085-1093; doi：10.1038/npp.2013.7; 2013年1月30日在线发表
Drug-dependent patients often relapse into drug use after treatment. Behavioral studies show that enhanced attentional bias to drug cues is a precursor of relapse. The present functional magnetic resonance imaging (fMRI) study examined whether brain regions involved in attentional bias are predictive of cocaine use after treatment. Attentional bias-related brain activity was measured-with a cocaine Stroop task-in cocaine-dependent patients during their first week in detoxification treatment and was used to predict cocaine use at 3-month follow-up. The predictive value of attentional bias-related brain activity in a priori defined regions of interest, in addition to other measures such as self-reports of substance severity, craving, and behavioral attentional bias were examined. The results show that craving in the week before treatment and individual variability in attentional bias-related activity in the dorsal anterior cingulate cortex (dACC) were significant predictors of days of cocaine use at 3-month follow-up and accounted for 45% in explained variance. Brain activity in the dACC uniquely contributed 22% of explained variance to the prediction model. These findings suggest that hyperactive attentional biasrelated brain activity in the dACC might be a biomarker of relapse vulnerability as early as in the first week of detoxification treatment. Ultimately, this may help to develop individually tailored treatment interventions to reduce relapse risk. Neuropsychopharmacology (2013) 38, 1085-1093; doi:10.1038/npp.2013.7; published online 30 January 2013