Regulation of TGF-β Superfamily Signaling by SMAD Mono-Ubiquitination.
Regulation of TGF-β Superfamily Signaling by SMAD Mono-Ubiquitination.
复制标题
SMAD 单泛素化对 TGF-β 超家族信号传导的调节
作者：
Xie F;Zhang Z;van Dam H;Zhang L;Zhou F
转化生长因子-β(Transform Growth Factor-β)超家族信号介质是多种生理和病理事件的重要调节因子。转化生长因子-β信号通过跨膜型I型和II型丝氨酸/苏氨酸激酶受体及其下游效应蛋白SmAD(果蝇母亲抗十磷蛋白)转导。大量研究已经证明了多泛素化对转化生长因子-β途径组分的修饰具有重要的调节作用。最近，一些研究还发现SMAD的单一泛素化是SMAD激活或失活的一种机制。相应地，SMAD蛋白的单一泛素化和随后的去泛素化在调控转化生长因子-β超家族信号转导中起着重要作用。这篇综述重点介绍了SMAD单泛素化调控的主要途径。
TGF-β(transforming growth factor-β) superfamily signaling mediators are important regulators of diverse physiological and pathological events. TGF-β signals are transduced by transmembrane type I and type II serine/threonine kinase receptors and their downstream effectors, the SMAD (drosophila mothers against decapentaplegic protein) proteins. Numerous studies have already demonstrated crucial regulatory roles for modification of TGF-β pathway components by poly-ubiquitination. Recently, several studies also uncovered mono-ubiquitination of SMADs as a mechanism for SMAD activation or inactivation. Mono-ubiquitination and subsequent deubiquitination of SMAD proteins accordingly play important roles in the control of TGF-β superfamily signaling. This review highlights the major pathways regulated by SMAD mono-ubiquitination.