MODULATION OF BOTH INTERLEUKIN-2 RECEPTOR EXPRESSION AND INTERLEUKIN-2 PRODUCTION DURING EXPERIMENTAL MURINE TRYPANOSOMA-CRUZI INFECTION
MODULATION OF BOTH INTERLEUKIN-2 RECEPTOR EXPRESSION AND INTERLEUKIN-2 PRODUCTION DURING EXPERIMENTAL MURINE TRYPANOSOMA-CRUZI INFECTION
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DOI：
10.1111/j.1365-3083.1989.tb01189.x
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发表时间：
1989-07-01
影响因子：
3.7
通讯作者：
ORN, A
中科院分区：
文献类型：
--
作者：
ROTTENBERG, M;LINDQVIST, C;ORN, A
在小鼠克氏锥虫感染的早期阶段，T细胞被大量激活。我们提供的数据表明，在增殖期(感染后4-7天)，大量的白介素2(IL-2)被分泌，IL-2受体被表达。刀豆球蛋白A诱导的增殖和IL-2的产生在急性感染后期(感染后约3周)明显减少。这种增殖不能通过外部添加IL-2来恢复。同时，高亲和力和低亲和力的IL-2受体的数量都急剧减少。这一减少并不是由于特定T细胞群的消除。体内注射重组IL-2未能改善对寄生虫的抵抗力，通过寄生虫血症和死亡率来衡量。
A massive activation of T cells takes place during the early stages of a Trypanosoma cruzi infection in mice. We present data indicating that substantial amounts of interleukin 2 (IL-2) are secreted and IL-2 receptors are expressed during the period of increased proliferation (4-7 days post infection). Both concanavalin A-induced proliferation and IL-2 production are markedly decreased later in the acute infection (around 3 weeks post infection). This proliferation cannot be restored by externally added IL-2. Simultaneously, there is a drastic reduction in the number of both high- and low-affinity IL-2 receptors. The reduction is not attributable to the elimination of a particular T-cell population. In vivo administration of recombinant IL-2 failed to improve resistance to T. cruzi parasites as measured by parasitaemia and mortality.