COMPARISON OF DRUG-METABOLIZING CAPABILITY IN ISOLATED VIABLE RAT HEPATOCYTES AND RENAL TUBULE FRAGMENTS
COMPARISON OF DRUG-METABOLIZING CAPABILITY IN ISOLATED VIABLE RAT HEPATOCYTES AND RENAL TUBULE FRAGMENTS
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DOI：
10.3109/00498257809060390
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发表时间：
1978-01-01
期刊：
影响因子：
1.8
通讯作者：
BRIDGES, JW
中科院分区：
文献类型：
--
作者：
FRY, JR;WIEBKIN, P;BRIDGES, JW
研究了乙氧基香豆素、联苯、苯并[a]芘、4-甲基伞形酮和苯甲酸等多种外源化合物在悬浮培养的大鼠肝肾小管上皮细胞中的代谢。肾细胞虽然具有较强的第二相代谢能力，但I相代谢水平很低。这些发现涉及细胞色素P-450和结合酶的生理作用，以及完整细胞系统在评估异种代谢器官间差异方面的价值。
The metabolism of a number of xenobiotics [ethoxycoumarin, biphenyl, benzo[a]pyrene, 4-methylumbelliferone and benzoic acid] was investigated in isolated viable rat hepatocytes and kidney tubule fragments in suspension. The level of Phase I metabolism was very low in the kidney cells although such cells possess appreciable Phase II metabolic capacity. These findings are discussed in relation to the physiological role of cytochrome P-450 and the conjugating enzymes, and the value of intact cell systems in assessing inter-organ differences in xenobiotic metabolism.