A Decade of Tissue Microarrays: Progress in the Discovery and Validation of Cancer Biomarkers
A Decade of Tissue Microarrays: Progress in the Discovery and Validation of Cancer Biomarkers
复制标题
DOI：
10.1200/jco.2008.17.3567
复制
发表时间：
2008-12-01
影响因子：
45.3
通讯作者：
Rimm, David L.
中科院分区：
文献类型：
--
作者：
Camp, Robert L.;Neumeister, Veronique;Rimm, David L.
2008年是现代组织微阵列（TMA）发展10周年。在过去的十年中，TMA的使用稳步增长，在所有癌症生物标志物研究中所占比例虽小但不断增加。基于TMA的研究越来越受欢迎，证明了它们在发现和验证新生物标志物方面的好处。这次审查将集中在这些好处，但也对TMA的故障和TMA研究的挑战，在过去的十年中已经克服。我们还将讨论PMA在癌症治疗最新革命（靶向药物治疗的使用）中的作用。
This year, 2008, marks the 10-year anniversary of the development of the modern tissue microarray (TMA). During the last decade, the use of TMAs has grown steadily and accounts for a small but increasing percentage of all cancer biomarker studies performed. The growing popularity of TMA-based studies attests to their benefits in the discovery and validation of new biomarkers. This review will focus on these benefits, but also on the faults of TMAs and the challenges of TMA studies that have been overcome in the last decade. We will also discuss the role of TMAs in the latest revolution in cancer treatment, the use of targeted drug therapy.