Role of renin-angiotensin system in blood pressure regulation in pregnancy.
Role of renin-angiotensin system in blood pressure regulation in pregnancy.
复制标题
肾素-血管紧张素系统在妊娠期血压调节中的作用。
DOI：
10.1016/s0140-6736(95)90012-8
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Edersheim,TG
中科院分区：
文献类型：
--
作者：
August,P;Mueller,FB;Sealey,JE;Edersheim,TG
我们给9名孕妇和8名非孕妇服用了卡托普利（25毫克）。从基线到服用卡托普利后60分钟，妊娠妇女的平均动脉压下降幅度明显大于非妊娠妇女（平均15.0 [SE 2.5] vs 5.2 [1.2] mm Hg;差异9·8 [95% Cl 3·9-15·9] mm Hg，p=0·0036），而妊娠组血浆肾素活性显著升高（18.0 [5.5] vs 4.5 [1.9] ng mL-1h-1;差异13.5 [0.71 - 26.5]，p= 0.043）。这些发现支持了妊娠期肾素-血管紧张素系统的刺激可以维持血压的假设。
We gave captopril (25 mg) to nine pregnant and eight non-pregnant women. From baseline to 60 min post-captopril, mean arterial pressure decreased significantly more in pregnant than in non-pregnant women (mean 15·0 [SE 2·5] vs 5·2 [1·2] mm Hg; difference 9·8 [95% Cl 3·9-15·9] mm Hg, p=0·0036), whereas plasma renin activity increased significantly more in the pregnant group (18·0 [5·5] vs 4·5 [1·9] ng mL-1h-1; difference 13·5 [0·71-26·5], p=0·043). These findings support the hypothesis that stimulation of the renin-angiotensin system in pregnancy maintains blood pressure.