Optimism and the brain: trait optimism mediates the protective role of the orbitofrontal cortex gray matter volume against anxiety
Optimism and the brain: trait optimism mediates the protective role of the orbitofrontal cortex gray matter volume against anxiety
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DOI：
10.1093/scan/nsv106
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发表时间：
2016-02-01
影响因子：
4.2
通讯作者：
Dolcos, Florin
中科院分区：
文献类型：
--
作者：
Dolcos, Sanda;Hu, Yifan;Dolcos, Florin
越来越多的证据表明，特质乐观和眶额皮层（OFC）是影响焦虑的人格和大脑因素，但它们之间关系的性质仍不清楚。在这里，研究了61名健康受试者的机制，这些受试者完成了特质乐观和焦虑的测量，并使用磁共振成像进行了结构扫描，研究了特质乐观和增加眶额皮层体积对焦虑症状的保护作用。首先，眶额皮层灰质体积（GMV）与乐观情绪的增加有关，乐观情绪的增加又与焦虑情绪的减少有关。第二，特质乐观主义介导了左眶额皮层体积和焦虑之间的关系，从而证明了该脑区GMV的增加通过增加乐观主义来防止焦虑症状。这些结果提供了关于大脑人格机制在健康功能中保护焦虑症状的新证据，并确定了旨在降低易感性和增加对情绪障碍的恢复力的预防和治疗干预的潜在目标。
Converging evidence identifies trait optimism and the orbitofrontal cortex (OFC) as personality and brain factors influencing anxiety, but the nature of their relationships remains unclear. Here, the mechanisms underlying the protective role of trait optimismand of increased OFC volume against symptoms of anxiety were investigated in 61 healthy subjects, who completed measures of trait optimism and anxiety, and underwent structural scanning using magnetic resonance imaging. First, the OFC gray matter volume (GMV) was associated with increased optimism, which in turn was associated with reduced anxiety. Second, trait optimismmediated the relation between the left OFC volume and anxiety, thus demonstrating that increased GMV in this brain region protects against symptoms of anxiety through increased optimism. These results provide novel evidence about the brain-personality mechanisms protecting against anxiety symptoms in healthy functioning, and identify potential targets for preventive and therapeutic interventions aimed at reducing susceptibility and increasing resilience against emotional disturbances.