Associations of C-reactive protein with measures of obesity, insulin resistance, and subclinical atherosclerosis in healthy, middle-aged women
Associations of C-reactive protein with measures of obesity, insulin resistance, and subclinical atherosclerosis in healthy, middle-aged women
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DOI：
10.1161/01.atv.19.8.1986
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发表时间：
1999-08-01
影响因子：
8.7
通讯作者：
Witteman, JCM
中科院分区：
文献类型：
--
作者：
Hak, AE;Stehouwer, CDA;Witteman, JCM
肥胖、胰岛素抵抗综合征和动脉粥样硬化密切相关，可能都是急性期反应增加的决定因素。在这项研究中，我们研究了C-反应蛋白（CRP）与肥胖的措施，胰岛素抵抗综合征的变量，和颈总动脉内膜中层厚度在186名健康，中年妇女从一般人群中选择的关系。相关性通过回归分析进行评估。CRP与体重指数（BMI）和腰围密切相关。CRP还与胰岛素抵抗综合征的其他变量相关，包括血压、胰岛素、高密度脂蛋白胆固醇、甘油三酯、载脂蛋白A1（相反）、纤溶酶原激活物抑制剂-1抗原和组织型纤溶酶原激活物抗原。CRP和胰岛素抵抗综合征变量之间的关联在控制BMI后消失，但仅对纤溶酶原激活物抑制剂-1抗原保持显著性。CRP与颈总动脉内膜中层厚度的相关性很弱，仅限于曾经吸烟者。BMI可解释CRP变异的29.7%，而颈总动脉内膜中层厚度仅解释3.7%。这项基于人群的研究结果表明，肥胖与健康中年女性的CRP密切相关。在该人群中，BMI解释了CRP与胰岛素抵抗综合征其他变量之间的关系。进一步的研究应该确定减肥是否能改善炎症状态。
Obesity, the insulin resistance syndrome, and atherosclerosis are closely linked and may all be determinants of an increased acute-phase response. In this study, we examined the relationship of C-reactive protein (CRP) with measures of obesity, variables of the insulin resistance syndrome, and intima-media thickness of the common carotid arteries in 186 healthy, middle-aged women selected from the general population. Associations were assessed by regression analysis. CRP was strongly associated with body mass index (BMI) and waist circumference. CRP was also associated with other variables of the insulin resistance syndrome, including blood pressure, insulin, high density lipoprotein cholesterol, triglycerides, apolipoprotein Al (inversely), plasminogen activator inhibitor-1 antigen, and tissue-type plasminogen activator antigen. Associations between CRP and the variables of the insulin resistance syndrome disappeared after controlling for BMI but remained significant for plasminogen activator inhibitor-1 antigen only. The association of CRP with common carotid artery intima-media thickness was weak and limited to ever-smokers. BMI explained 29.7% of the variance of CRP, whereas common carotid artery intima-media thickness explained only 3.7%. The results of this population-based study indicate that adiposity is strongly associated with CRP in healthy, middle-aged women. In this population, BMI accounted for the relationship between CRP and other variables of the insulin resistance syndrome. Further studies should determine whether losing weight ameliorates the inflammatory state.